Protein Alignment TyrRII and Htr5b

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_034613.2
• Gene: Htr5b / 15564
• MGIID: 96284
• Length: 370
• Species: Mus musculus
• Alignment Length: 550
• Identity: 123/550 - (22%)
• Similarity: 193/550 - (35%)
• Gaps: 224/550 - (40%)

  Fly    24 ASGNS-NSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILV 87
            :||.| .|:.|.|:|      ||.:             |..:::.|       |.|.:.:::|:.
Mouse    27 SSGRSMGSTPGGLIL------PGRE-------------PPFSAFTV-------LVVTLLVLLIVA 65

  Fly    88 TVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVV--LYITGTWRFGWILCDIW 150
            |.:.|.||::.:|..|....|.:..|.:.|::|.||...|||.|:|  |.:...|:.|..||.:|
Mouse    66 TFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSVGRRWQLGRSLCHVW 130

  Fly   151 ISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVW-ITALSITCPPYLGW 214
            ||.|:|.|:.||.::.||:||||..:|:.|.|:.:.|| |.:.|||.:.| ::||....|...||
Mouse   131 ISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRS-RASALMIAITWALSALIALAPLLFGW 194

  Fly   215 YEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKI----GYVLTSRRQRIVRDAYS 275
            .|.  :.|....|:.:|...|.|||..|:|::||.|:|:||.||    .:....||:.:|
Mouse   195 GEA--YDARLQRCQVSQEPSYAVFSTCGAFYLPLAVVLFVYWKIYKAAKFRFGRRRRAVV----- 252

  Fly   276 ERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKC 340
                                                        |..||..|
Mouse   253 --------------------------------------------PLPATTQA------------- 260

  Fly   341 SKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGM 405
                                     |..|...|:|..:|..:
Mouse   261 -------------------------KEAPPESEMVFTARRRA----------------------- 277

  Fly   406 HYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGS 470
                                        ||..:|:.....|.|:|
Mouse   278 ----------------------------TVTFQTSGDSWREQKEK-------------------- 294

  Fly   471 HGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPF--LPRPAVLEDL 533
                                    :.|..:.|::|..:.||:|||:..|:.|.  ...|.:.:.:
Mouse   295 ------------------------RAAMMVGILIGVFVLCWIPFFLTELISPLCACSLPPIWKSI 335

  Fly   534 MFGFTWIGWVNCAINPFIYAFYNPDFRTAF 563
               |.|:|:.|...||.||..:|.::..||
Mouse   336 ---FLWLGYSNSFFNPLIYTAFNKNYNNAF 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	73/198 (37%)
		TM helix 1	78..101	CDD:410628	6/22 (27%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	6/16 (38%)
		TM helix 5	233..256	CDD:410628	11/22 (50%)
		7tm_GPCRs	<491..563	CDD:475119	20/73 (27%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
Htr5b	NP_034613.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		4/8 (50%)
		7tm_GPCRs	65..362	CDD:475119	107/484 (22%)
		TM helix 2	88..110	CDD:410628	8/21 (38%)
		TM helix 3	128..150	CDD:410628	10/21 (48%)
		TM helix 4	173..189	CDD:410628	6/15 (40%)
		TM helix 5	211..234	CDD:410628	11/22 (50%)
		TM helix 6	297..319	CDD:410628	8/21 (38%)
		TM helix 7	330..355	CDD:410628	8/27 (30%)