Protein Alignment TyrRII and Htr5a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_032340.2
• Gene: Htr5a / 15563
• MGIID: 96283
• Length: 357
• Species: Mus musculus
• Alignment Length: 524
• Identity: 121/524 - (23%)
• Similarity: 194/524 - (37%)
• Gaps: 214/524 - (40%)

  Fly    69 SMAWPKSLA----------------VAVFLVIILVTVVG---------NTLVILAVLTTRRLRTV 108
            |::.|.||.                ::.|.|::| |::|         |.||:..:|..|....|
Mouse    11 SLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVL-TLLGFLAAATFTWNLLVLATILKVRTFHRV 74

  Fly   109 TNCFVMNLAITDWLVGTCVMPPSVVLYITG-TWRFGWILCDIWISLDILLCSGSILSLCAISLDR 172
            .:..|.::||:|.||...|||.|:|..::| .|:.|..||.:||:.|:|.|:.||.::.||:|||
Mouse    75 PHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDR 139

  Fly   173 YLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYL-GWYEVGRHQAEFVDCRYNQNKGYV 236
            |.::|:.|.|:.:.| ||::.:|||:.|..:..|:..|.| ||.|.....:|  :|:.::...|.
Mouse   140 YWSITRHLEYTLRTR-KRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSE--ECQVSREPSYT 201

  Fly   237 VFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTK 301
            |||.:|:|::||.|:|:||.||                 .|.|.:.
Mouse   202 VFSTVGAFYLPLCVVLFVYWKI-----------------YRAAKFR------------------- 230

  Fly   302 WLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFK 366
             :.:||:    ||: .|.|.|.....|..|...|                           .|.:
Mouse   231 -MGSRKT----NSV-SPVPEAVEVKNATQHPQMV---------------------------FTVR 262

  Fly   367 HQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTT 431
            |.
Mouse   263 HA--------------------------------------------------------------- 264

  Fly   432 TNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKT 496
              ||..:|    |.:..::|::||:
Mouse   265 --TVTFQT----EGDTWREQKEQRA---------------------------------------- 283

  Fly   497 AKTLTIVMGGLIACWLPFFVYYLLIPFL--PRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDF 559
            |..:.|::|..:.||.||||..|:.|..  ..||:.:.:   |.|:|:.|...||.||..:|..:
Mouse   284 ALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSI---FLWLGYSNSFFNPLIYTAFNRSY 345

  Fly   560 RTAF 563
            .:||
Mouse   346 SSAF 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	72/202 (36%)
		TM helix 1	78..101	CDD:410628	8/31 (26%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	9/21 (43%)
		TM helix 4	194..210	CDD:410628	5/15 (33%)
		TM helix 5	233..256	CDD:410628	11/22 (50%)
		7tm_GPCRs	<491..563	CDD:475119	22/73 (30%)
		TM helix 6	497..519	CDD:320098	9/21 (43%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
Htr5a	NP_032340.2	7tm_GPCRs	41..349	CDD:475119	114/492 (23%)
		TM helix 1	43..67	CDD:410628	6/24 (25%)
		TM helix 2	76..98	CDD:410628	9/21 (43%)
		TM helix 3	115..137	CDD:410628	9/21 (43%)
		TM helix 4	160..176	CDD:410628	5/15 (33%)
		TM helix 5	198..221	CDD:410628	11/22 (50%)
		TM helix 6	284..306	CDD:410628	9/21 (43%)
		TM helix 7	317..342	CDD:410628	9/27 (33%)