Protein Alignment TyrRII and Htr4

DIOPT Version :9

• Sequence 1: NP_001262682.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_032339.2
• Gene: Htr4 / 15562
• MGIID: 109246
• Length: 388
• Species: Mus musculus
• Alignment Length: 518
• Identity: 118/518 - (22%)
• Similarity: 179/518 - (34%)
• Gaps: 211/518 - (40%)

  Fly    74 KSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTV-TNCFVMNLAITDWLVGTCVMPPSVVLYIT 137
            |.:.:....|:||:.::||.||::||...|:||.: ||.|:::||..|.||...|||...:..:.
Mouse    19 KVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQ 83

  Fly   138 GTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAV-TQPLTYSKKRRSKRLALLMILVVWI 201
            ..|.:|.:.|.:..|||:||.:.||..||.||||||.|: .|||.|..|....|:| ||:...|:
Mouse    84 DIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIA-LMLGGCWV 147

  Fly   202 TALSITCPPYL-GWYEVG----------RHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVY 255
            ..:.|:..|.: ||..:|          .|.:....|.:..||.|.:..::.:|:||..:|:..|
Mouse   148 LPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAY 212

  Fly   256 VKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPP 320
            .:|                             :::..||
Mouse   213 YRI-----------------------------YVTAKEH-------------------------- 222

  Fly   321 SAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIH 385
                                                                             
Mouse   223 ----------------------------------------------------------------- 222

  Fly   386 CSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQK 450
                                                                         |:|.
Mouse   223 -------------------------------------------------------------AQQI 226

  Fly   451 QQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFF 515
            |..||:.....        |..|.:..:..|||       :.::|.||||.::||....||.|||
Mouse   227 QMLQRAGATSE--------SRPQPADQHSTHRM-------RTETKAAKTLCVIMGCFCFCWAPFF 276

  Fly   516 VYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRPP 578
            |..::.||:.. .|.|.:...|.|:|::|..:|||:|||.|..||.||..:.|....:.||||
Mouse   277 VTNIVDPFIDY-TVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPP 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	54/131 (41%)
		7tm_1	91..>277	CDD:278431	65/198 (33%)
Htr4	NP_032339.2	7tmA_5-HT4	20..323	CDD:320184	110/500 (22%)
		TM helix 1	21..47	CDD:320184	9/25 (36%)
		TM helix 2	55..81	CDD:320184	11/25 (44%)
		TM helix 3	93..123	CDD:320184	17/29 (59%)
		TM helix 4	136..159	CDD:320184	7/23 (30%)
		TM helix 5	189..218	CDD:320184	9/57 (16%)
		TM helix 6	252..282	CDD:320184	13/29 (45%)
		TM helix 7	291..316	CDD:320184	11/24 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870