Protein Alignment TyrRII and Htr2b

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_006529209.1
• Gene: Htr2b / 15559
• MGIID: 109323
• Length: 495
• Species: Mus musculus
• Alignment Length: 514
• Identity: 119/514 - (23%)
• Similarity: 184/514 - (35%)
• Gaps: 179/514 - (34%)

  Fly    77 AVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVV-LYITGTW 140
            |..:.|.:|:.|:.||.||||||...:||:..||.|:|:|||.|.|||..|||.::: :.....|
Mouse    56 AALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIW 120

  Fly   141 RFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITAL- 204
            .....||..|:.||:|..:.||:.|||||||||:|:.:|: .:.:..|:..|.:.|.|||:.::
Mouse   121 PLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPI-QANQCNSRATAFIKITVVWLISIG 184

  Fly   205 ---------------SITCPPYLGWYEVGRHQAEFVDCRYNQNK--GYVVFSAMGSFFIPLTVML 252
                           .|..|..:...|........|.|...:::  .::||.::.:||.|||:|:
Mouse   185 MWGMPLFPYGQNASSGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMV 249

  Fly   253 YVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHD 317
            ..|....:.|..:       ||..:...                       |.|.:||..
Mouse   250 VTYFLTIHTLQKK-------AYLVKNKP-----------------------PQRLTRWTV----- 279

  Fly   318 PPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSS 382
                                                               ||.: |.|.|..||
Mouse   280 ---------------------------------------------------PTVF-LREDSSFSS 292

  Fly   383 LIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEA 447
                         |...:...|.|                                 .:|:...:
Mouse   293 -------------PEKVAMLDGSH---------------------------------RDKILPNS 311

  Fly   448 KQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWL 512
            ..:...:|.|            |.|::|           ..|...:.:.:|.|.:|....:..|.
Mouse   312 SDETLMRRMS------------SVGKRS-----------AQTISNEQRASKALGVVFFLFLLMWC 353

  Fly   513 PFFVYYLLIPFLP--RPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWR-LTC 568
            |||:..|.:....  ....|:.|:..|.|||:|:..:||.||..:|..||.||.| :||
Mouse   354 PFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITC 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	68/210 (32%)
		TM helix 1	78..101	CDD:410628	11/22 (50%)
		TM helix 2	110..132	CDD:410628	13/21 (62%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	5/31 (16%)
		TM helix 5	233..256	CDD:410628	8/24 (33%)
		7tm_GPCRs	<491..563	CDD:475119	22/73 (30%)
		TM helix 6	497..519	CDD:320098	7/21 (33%)
		TM helix 7	531..556	CDD:320098	10/24 (42%)
Htr2b	XP_006529209.1	7tm_GPCRs	54..413	CDD:475119	119/514 (23%)
		TM helix 1	56..80	CDD:410628	12/23 (52%)
		TM helix 2	89..111	CDD:410628	13/21 (62%)
		TM helix 3	128..150	CDD:410628	10/21 (48%)
		TM helix 4	173..205	CDD:410628	5/31 (16%)
		TM helix 5	230..253	CDD:410628	8/22 (36%)
		TM helix 6	338..360	CDD:410628	7/21 (33%)
		TM helix 7	374..399	CDD:410628	10/24 (42%)