DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and Htr1d

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_032335.2 Gene:Htr1d / 15552 MGIID:96276 Length:374 Species:Mus musculus


Alignment Length:520 Identity:152/520 - (29%)
Similarity:211/520 - (40%) Gaps:174/520 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 GVP---SMNSYLVSMAW-PKSL------AVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFV 113
            |:|   |..|..|:.|| |:.|      .|.|..||.|.||:.|..|:..:|.|::|.|..|..:
Mouse    10 GLPQEASNRSLNVTGAWDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLI 74

  Fly   114 MNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQ 178
            .:||.||.||...|||.|:....|.||.||.||||||:|.||..|:.|||.||.|:||||.|:|.
Mouse    75 GSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITD 139

  Fly   179 PLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNK-GYVVFSAMG 242
            .|.|| |||:...|..||..|||.::.|:.|| |.|.:...|: |..||..|.:: .|.::|..|
Mouse   140 ALEYS-KRRTAGHAAAMIAAVWIISICISIPP-LFWRQATAHE-EMSDCLVNTSQISYTIYSTCG 201

  Fly   243 SFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRK 307
            :|:||..:::.:|   |.:..:.|.||:                                     
Mouse   202 AFYIPSILLIILY---GRIYVAARSRIL------------------------------------- 226

  Fly   308 SRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFY 372
                     :||              |:...:.:.....||:||                     
Mouse   227 ---------NPP--------------SLYGKRFTTAQLITGSAG--------------------- 247

  Fly   373 ELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVAL 437
                    |||  ||.      .|.:|.  |..|.||:...|                  |.|.:
Mouse   248 --------SSL--CSL------NPSLHE--SHTHTVGSPLFF------------------NQVKI 276

  Fly   438 ETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTI 502
            :..:.: .|.|                                     |:|.. |:.|..|||.|
Mouse   277 KLADSI-LERK-------------------------------------RISAA-RERKATKTLGI 302

  Fly   503 VMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRL 566
            ::|..|.|||||||..|::|.......:...:|. |||:|::|..|||.||..:|.|||.||.::
Mouse   303 ILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKV 367

  Fly   567  566
            Mouse   368  367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 83/192 (43%)
TM helix 1 78..101 CDD:410628 9/22 (41%)
TM helix 2 110..132 CDD:410628 10/21 (48%)
TM helix 3 148..170 CDD:410628 13/21 (62%)
TM helix 4 194..210 CDD:410628 6/15 (40%)
TM helix 5 233..256 CDD:410628 6/23 (26%)
7tm_GPCRs <491..563 CDD:475119 32/72 (44%)
TM helix 6 497..519 CDD:320098 13/21 (62%)
TM helix 7 531..556 CDD:320098 11/25 (44%)
Htr1dNP_032335.2 7tm_GPCRs 32..364 CDD:475119 141/493 (29%)
TM helix 1 38..62 CDD:320455 9/23 (39%)
TM helix 2 71..93 CDD:320455 10/21 (48%)
TM helix 3 109..131 CDD:320455 13/21 (62%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 132..134 1/1 (100%)
TM helix 4 154..170 CDD:320455 6/15 (40%)
TM helix 5 192..215 CDD:320455 7/25 (28%)
TM helix 6 297..319 CDD:320455 13/21 (62%)
TM helix 7 332..357 CDD:320455 11/24 (46%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 349..353 2/3 (67%)

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