DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and Htr1b

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_034612.1 Gene:Htr1b / 15551 MGIID:96274 Length:386 Species:Mus musculus


Alignment Length:528 Identity:142/528 - (26%)
Similarity:210/528 - (39%) Gaps:179/528 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 AGKLGVP--------SMNSYL----VSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRT 107
            |.:.|||        |.:.|:    :::.| |.|.||:..:|.|.|.:.|..||..|..||:|.|
Mouse    15 ASQTGVPLTNLSHNCSADGYIYQDSIALPW-KVLLVALLALITLATTLSNAFVIATVYRTRKLHT 78

  Fly   108 VTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDR 172
            ..|..:.:||:||.||...|||.|.:..:||.|..|.::||.|:|.||..|:.||:.||.|:|||
Mouse    79 PANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDR 143

  Fly   173 YLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKG-YV 236
            |.|:|..:.||.||..|| |.:||::||:.::||:.||:. |.: .:.:.|.:||..|.:.. |.
Mouse   144 YWAITDAVEYSAKRTPKR-AAIMIVLVWVFSISISLPPFF-WRQ-AKAEEEMLDCFVNTDHVLYT 205

  Fly   237 VFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTK 301
            |:|.:|:|::|..:::.:|   |.:....|.||::.                         ||.|
Mouse   206 VYSTVGAFYLPTLLLIALY---GRIYVEARSRILKQ-------------------------TPNK 242

  Fly   302 WLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKC--SKCSKCSSATGTAGAGAGAGVVDKTLT 364
               ..|...|...:.|.|          |..|||..  |:.....|.:|:               
Mouse   243 ---TGKRLTRAQLITDSP----------GSTSSVTSINSRAPDVPSESGS--------------- 279

  Fly   365 FKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTT 429
                |.:...|:| |:|.                                               
Mouse   280 ----PVYVNQVKV-RVSD----------------------------------------------- 292

  Fly   430 TTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDS 494
                  ||...:||.|                                             .|:.
Mouse   293 ------ALLEKKKLMA---------------------------------------------ARER 306

  Fly   495 KTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPD 558
            |..|||.|::|..|.||||||:..|::|...........:|. |.|:|::|..|||.||...|.|
Mouse   307 KATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNED 371

  Fly   559 FRTAFWRL 566
            |:.||.:|
Mouse   372 FKQAFHKL 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 76/192 (40%)
TM helix 1 78..101 CDD:410628 9/22 (41%)
TM helix 2 110..132 CDD:410628 10/21 (48%)
TM helix 3 148..170 CDD:410628 11/21 (52%)
TM helix 4 194..210 CDD:410628 6/15 (40%)
TM helix 5 233..256 CDD:410628 6/23 (26%)
7tm_GPCRs <491..563 CDD:475119 29/72 (40%)
TM helix 6 497..519 CDD:320098 12/21 (57%)
TM helix 7 531..556 CDD:320098 10/25 (40%)
Htr1bNP_034612.1 7tmA_5-HT1B_1D 42..376 CDD:320455 133/496 (27%)
TM helix 1 47..73 CDD:320455 10/25 (40%)
TM helix 2 80..106 CDD:320455 11/25 (44%)
TM helix 3 118..148 CDD:320455 17/29 (59%)
DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 142..144 1/1 (100%)
TM helix 4 160..183 CDD:320455 11/24 (46%)
TM helix 5 201..230 CDD:320455 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 255..278 8/32 (25%)
TM helix 6 303..333 CDD:320455 15/29 (52%)
TM helix 7 344..369 CDD:320455 10/24 (42%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 361..365 2/3 (67%)

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