Protein Alignment TyrRII and Htr1a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_032334.2
• Gene: Htr1a / 15550
• MGIID: 96273
• Length: 421
• Species: Mus musculus
• Alignment Length: 558
• Identity: 148/558 - (26%)
• Similarity: 233/558 - (41%)
• Gaps: 147/558 - (26%)

  Fly    22 TVASGNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMN-SYLVSMAWPKSLAVAVFLVII 85
            ::..||:.:         ||..|      .|.|....|:.::. ||.|       :...:...:|
Mouse     5 SLGQGNNTT---------TSLEP------FGTGGNDTGLSNVTFSYQV-------ITSLLLGTLI 47

  Fly    86 LVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIW 150
            ...|:||..|:.|:...|.|:.|.|..:.:||:||.:|...|:|.:.:..:...|..|.:.||::
Mouse    48 FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLF 112

  Fly   151 ISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWY 215
            |:||:|.|:.|||.||||:||||.|:|.|:.|..||..:|.|.| |.:.|:....|:.||.|||
Mouse   113 IALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAAL-ISLTWLIGFLISIPPMLGW- 175

  Fly   216 EVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTAD 280
            .....::...:|..:::.||.::|..|:|:|||.:||.:|   |.:..:.|.||.:
Mouse   176 RTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLY---GRIFRAARFRIRK--------- 228

  Fly   281 YDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSS 345
                              ..|.:..:.:...|.:...|||..:.|    |...|..|.:.:: :.
Mouse   229 ------------------TVKKVEKKGAGTSFGTSSAPPPKKSLN----GQPGSGDCRRSAE-NR 270

  Fly   346 ATGT--AGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYV 408
            |.||  |......|..|.||         |::||                            |.|
Mouse   271 AVGTPCANGAVRQGEDDATL---------EVIEV----------------------------HRV 298

  Fly   409 GTEASFSDTCLGGNVSNNTTTTTTNTV--ALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSH 471
            |...        |::...:.:..|:.|  .||...:..||||:|.
Mouse   299 GNSK--------GHLPLPSESGATSYVPACLERKNERTAEAKRKM-------------------- 335

  Fly   472 GQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG 536
                             ...|:.||.|||.|:||..|.||||||:..|::||......:.:|:..
Mouse   336 -----------------ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGA 383

  Fly   537 -FTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICK 573
             ..|:|:.|..:||.|||::|.||:.||.::.....|:
Mouse   384 IINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	69/191 (36%)
		TM helix 1	78..101	CDD:410628	6/22 (27%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	13/21 (62%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	10/22 (45%)
		7tm_GPCRs	<491..563	CDD:475119	31/72 (43%)
		TM helix 6	497..519	CDD:320098	13/21 (62%)
		TM helix 7	531..556	CDD:320098	9/25 (36%)
Htr1a	NP_032334.2	7tmA_5-HT1A_vertebrates	37..411	CDD:320453	135/499 (27%)
		TM helix 1	38..64	CDD:320453	6/25 (24%)
		TM helix 2	71..97	CDD:320453	8/25 (32%)
		TM helix 3	109..139	CDD:320453	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	8/22 (36%)
		TM helix 5	192..221	CDD:320453	12/31 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..268		8/34 (24%)
		TM helix 6	338..368	CDD:320453	17/29 (59%)
		TM helix 7	379..404	CDD:320453	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400		2/3 (67%)