Protein Alignment TyrRII and ADRB3

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_000016.1
• Gene: ADRB3 / 155
• HGNCID: 288
• Length: 408
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 145/564 - (25%)
• Similarity: 211/564 - (37%)
• Gaps: 214/564 - (37%)

  Fly    40 TSAAPGGDVMA----TGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVL 100
            :|.||..|:..    |...:|..|||          |..:||.|:..:.:|.||.||.|||:|:.
Human     9 SSLAPWPDLPTLAPNTANTSGLPGVP----------WEAALAGALLALAVLATVGGNLLVIVAIA 63

  Fly   101 TTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSL 165
            .|.||:|:||.||.:||..|.::|..|:||:..|.:||.|..|...|::|.|:|:|..:.||.:|
Human    64 WTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETL 128

  Fly   166 CAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLG-WYEVGRHQAEFVDCRY 229
            ||:::|||||||.||.|. ...:||.|...:::||:.:.:::..|.:. |:.||. .||...|..
Human   129 CALAVDRYLAVTNPLRYG-ALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGA-DAEAQRCHS 191

  Fly   230 N-------QNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDN 287
            |       .|..||:.|:..||::||.|||:||.:: :|:.:|:.|::|....
Human   192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARV-FVVATRQLRLLRGELG------------ 243

  Fly   288 FISESEHYHCTPTKWLPNRKSRWRFNSLHDPP-PSAATNAAAKGHQSSVKCSKCSKCSSATGTAG 351
                                   ||.....|| ||.:...|..|           .|:...|...
Human   244 -----------------------RFPPEESPPAPSRSLAPAPVG-----------TCAPPEGVPA 274

  Fly   352 AGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSD 416
            .|
Human   275 CG--------------------------------------------------------------- 276

  Fly   417 TCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHH 481
                                                                             
Human   277 ----------------------------------------------------------------- 276

  Fly   482 RMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLL-----IPFLPRPAVLEDLMFGFTWIG 541
            |.|.|: ...|:.:...||.::||....||||||:..:|     ...:|.||.|     ...|:|
Human   277 RRPARL-LPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFL-----ALNWLG 335

  Fly   542 WVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRPPNHLAMFR 585
            :.|.|.||.||. .:||||:||.||.||  |.::.||...|..|
Human   336 YANSAFNPLIYC-RSPDFRSAFRRLLCR--CGRRLPPEPCAAAR 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	79/199 (40%)
		TM helix 1	78..101	CDD:410628	10/22 (45%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	9/21 (43%)
		TM helix 4	194..210	CDD:410628	2/15 (13%)
		TM helix 5	233..256	CDD:410628	11/22 (50%)
		7tm_GPCRs	<491..563	CDD:475119	28/76 (37%)
		TM helix 6	497..519	CDD:320098	10/21 (48%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:475119	120/488 (25%)
		TM helix 2	73..95	CDD:320625	10/21 (48%)
		TM helix 3	111..133	CDD:320625	9/21 (43%)
		TM helix 4	156..172	CDD:320625	2/15 (13%)
		TM helix 5	202..225	CDD:320625	11/22 (50%)
		TM helix 6	291..313	CDD:320625	10/21 (48%)
		TM helix 7	325..350	CDD:320625	11/30 (37%)