DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and ADRB2

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000015.2 Gene:ADRB2 / 154 HGNCID:286 Length:413 Species:Homo sapiens


Alignment Length:553 Identity:124/553 - (22%)
Similarity:187/553 - (33%) Gaps:223/553 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 GNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVV 90
            |...:....||....|.||..||....                ...|...:.: |..:|:|..|.
Human     2 GQPGNGSAFLLAPNGSHAPDHDVTQER----------------DEVWVVGMGI-VMSLIVLAIVF 49

  Fly    91 GNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDI 155
            ||.|||.|:....||:||||.|:.:||..|.::|..|:|......:...|.||...|:.|.|:|:
Human    50 GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDV 114

  Fly   156 LLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWI-TALSITCPPYLGWYEVGR 219
            |..:.||.:||.|::|||.|:|.|..| :...:|..|.::||:||| :.|:...|..:.||. ..
Human   115 LCVTASIETLCVIAVDRYFAITSPFKY-QSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYR-AT 177

  Fly   220 HQAEFVDCRYNQ-------NKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSER 277
            || |.::|..|:       |:.|.:.|::.||::||.:|::||.::......:.|:|        
Human   178 HQ-EAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKI-------- 233

  Fly   278 TADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSK 342
                                        .||..||:                             
Human   234 ----------------------------DKSEGRFH----------------------------- 241

  Fly   343 CSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHY 407
                                              |..||                          
Human   242 ----------------------------------VQNLS-------------------------- 246

  Fly   408 VGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHG 472
                                                     |.:|..|:             .||
Human   247 -----------------------------------------QVEQDGRT-------------GHG 257

  Fly   473 QQSHHNHHHRMPMRVST--TKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMF 535
                        :|.|:  ..::.|..|||.|:||....||||||:.. ::..:....:.:::..
Human   258 ------------LRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVN-IVHVIQDNLIRKEVYI 309

  Fly   536 GFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTC 568
            ...|||:||...||.||. .:||||.||..|.|
Human   310 LLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLC 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 70/199 (35%)
TM helix 1 78..101 CDD:410628 10/22 (45%)
TM helix 2 110..132 CDD:410628 8/21 (38%)
TM helix 3 148..170 CDD:410628 9/21 (43%)
TM helix 4 194..210 CDD:410628 6/16 (38%)
TM helix 5 233..256 CDD:410628 8/22 (36%)
7tm_GPCRs <491..563 CDD:475119 26/71 (37%)
TM helix 6 497..519 CDD:320098 12/21 (57%)
TM helix 7 531..556 CDD:320098 9/24 (38%)
ADRB2NP_000015.2 7tmA_Beta2_AR 34..336 CDD:341355 111/498 (22%)
TM helix 1 35..61 CDD:341355 10/26 (38%)
TM helix 2 68..95 CDD:341355 9/26 (35%)
TM helix 3 106..136 CDD:341355 14/29 (48%)
TM helix 4 148..171 CDD:341355 8/22 (36%)
TM helix 5 196..228 CDD:341355 10/31 (32%)
TM helix 6 266..296 CDD:341355 13/30 (43%)
TM helix 7 305..330 CDD:341355 9/25 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..413
PDZ-binding 410..413
Blue background indicates that the domain is not in the aligned region.

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