DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and ADRB1

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000675.1 Gene:ADRB1 / 153 HGNCID:285 Length:477 Species:Homo sapiens


Alignment Length:566 Identity:143/566 - (25%)
Similarity:210/566 - (37%) Gaps:211/566 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 SSDGTLLLIQTSAAPGGDVMATGAGAGKLGVP-----------SMNSYLVSMAWPKSLAVAVFLV 83
            |..|.|    :||||..|..||   |.:|.||           |.:...:|..|...:.:.:.|:
Human    11 SEPGNL----SSAAPLPDGAAT---AARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALI 68

  Fly    84 IILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCD 148
            ::|: |.||.|||:|:..|.||:|:||.|:|:||..|.::|..|:|....:.:.|.|.:|...|:
Human    69 VLLI-VAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCE 132

  Fly   149 IWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSK---KRRSKRLALLMILVVW-ITALSITCP 209
            :|.|:|:|..:.||.:||.|:||||||:|.|..|..   :.|::.|    :..|| |:||....|
Human   133 LWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGL----VCTVWAISALVSFLP 193

  Fly   210 PYLGWYEVGRHQAE--FVD---CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRI 269
            ..:.|:.....:|.  :.|   |.:..|:.|.:.|::.||::||.:|.:||:           |:
Human   194 ILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYL-----------RV 247

  Fly   270 VRDAYSERTADYDVDGDNFI-------SESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAA 327
            .|:| .::....|.....|:       |.|......|.                 |||.....||
Human   248 FREA-QKQVKKIDSCERRFLGGPARPPSPSPSPVPAPA-----------------PPPGPPRPAA 294

  Fly   328 AKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCK 392
            |           .:....|.|.||              |.:|        |||.:|         
Human   295 A-----------AATAPLANGRAG--------------KRRP--------SRLVAL--------- 317

  Fly   393 YGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSS 457
                                                                             
Human   318 ----------------------------------------------------------------- 317

  Fly   458 FDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIP 522
                                              |:.|..|||.|:||....||||||:..::..
Human   318 ----------------------------------REQKALKTLGIIMGVFTLCWLPFFLANVVKA 348

  Fly   523 FLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTC 568
            | .|..|.:.|...|.|:|:.|.|.||.||. .:||||.||..|.|
Human   349 F-HRELVPDRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLC 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 68/200 (34%)
TM helix 1 78..101 CDD:410628 9/22 (41%)
TM helix 2 110..132 CDD:410628 9/21 (43%)
TM helix 3 148..170 CDD:410628 9/21 (43%)
TM helix 4 194..210 CDD:410628 5/16 (31%)
TM helix 5 233..256 CDD:410628 8/22 (36%)
7tm_GPCRs <491..563 CDD:475119 31/71 (44%)
TM helix 6 497..519 CDD:320098 12/21 (57%)
TM helix 7 531..556 CDD:320098 10/24 (42%)
ADRB1NP_000675.1 7tmA_Beta1_AR 59..387 CDD:320624 122/504 (24%)
TM helix 1 60..86 CDD:320624 9/26 (35%)
TM helix 2 93..120 CDD:320624 10/26 (38%)
TM helix 3 131..161 CDD:320624 16/29 (55%)
TM helix 4 175..193 CDD:320624 6/21 (29%)
TM helix 5 221..253 CDD:320624 13/43 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..307 11/65 (17%)
TM helix 6 317..347 CDD:320624 15/137 (11%)
TM helix 7 356..381 CDD:320624 10/25 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 403..477
PDZ-Binding 474..477
Blue background indicates that the domain is not in the aligned region.

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