DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and ADRA2C

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000674.2 Gene:ADRA2C / 152 HGNCID:283 Length:462 Species:Homo sapiens


Alignment Length:584 Identity:161/584 - (27%)
Similarity:238/584 - (40%) Gaps:160/584 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 SKLLSTALTVASGNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSY----LVSMAWPK 74
            |..|:.||.||:....::.|.     .....||...|:||..|    |....|    :..:|   
Human     3 SPALAAALAVAAAAGPNASGA-----GERGSGGVANASGASWG----PPRGQYSAGAVAGLA--- 55

  Fly    75 SLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGT 139
              ||..||::.  |||||.||::||||:|.||...|.|:::||..|.||.|.|||.|:...:...
Human    56 --AVVGFLIVF--TVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAY 116

  Fly   140 WRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITAL 204
            |.||.:.|.::::||:|.|:.||:.|||||||||.:|||.:.|:.||..:|:. ..|:.||:.:.
Human   117 WYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVK-ATIVAVWLISA 180

  Fly   205 SITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRI 269
            .|:.||.:..|. ....|.:..|..|....|::.|.:||||.|..:|..||.:| |.:...|.|.
Human   181 VISFPPLVSLYR-QPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARI-YRVAKLRTRT 243

  Fly   270 VRDAYSERTADYDVDGDNFISES---------EHYHCTPTKWLPNRKSRWRFNSLHDPP----PS 321
            :    ||:.|....||.:..:|:         |:.||.|                  ||    |.
Human   244 L----SEKRAPVGPDGASPTTENGLGAAAGAGENGHCAP------------------PPADVEPD 286

  Fly   322 AATNAAAKGHQSSVKCSKCSKCSSATGTAGA----GAGAGVVDK-TLTFKHQPTFYELVEVSRLS 381
            .::.||.:..:.........:.:.|.|.||.    |||.|..:. .||....|            
Human   287 ESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSP------------ 339

  Fly   382 SLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAE 446
                         ||                       ||.:|..::.:....::          
Human   340 -------------GP-----------------------GGRLSRASSRSVEFFLS---------- 358

  Fly   447 AKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACW 511
               ::::.|||                         :..|.....|:.:....|.:|||..:.||
Human   359 ---RRRRARSS-------------------------VCRRKVAQAREKRFTFVLAVVMGVFVLCW 395

  Fly   512 LPFFVYYLLIPF------LPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCR 569
            .|||..|.|...      :|.|     |...|.|||:.|.::||.||..:|.|||.:|..:..|
Human   396 FPFFFSYSLYGICREACQVPGP-----LFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFR 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 79/191 (41%)
TM helix 1 78..101 CDD:410628 12/22 (55%)
TM helix 2 110..132 CDD:410628 11/21 (52%)
TM helix 3 148..170 CDD:410628 10/21 (48%)
TM helix 4 194..210 CDD:410628 4/15 (27%)
TM helix 5 233..256 CDD:410628 9/22 (41%)
7tm_GPCRs <491..563 CDD:475119 28/77 (36%)
TM helix 6 497..519 CDD:320098 9/21 (43%)
TM helix 7 531..556 CDD:320098 10/24 (42%)
ADRA2CNP_000674.2 7tmA_alpha2C_AR 60..448 CDD:320446 141/505 (28%)
TM helix 2 86..112 CDD:320446 12/25 (48%)
TM helix 3 124..154 CDD:320446 16/29 (55%)
TM helix 4 166..189 CDD:320446 7/23 (30%)
TM helix 5 207..236 CDD:320446 12/29 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..347 29/166 (17%)
TM helix 6 375..405 CDD:320446 11/29 (38%)
TM helix 7 416..441 CDD:320446 11/29 (38%)

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