Protein Alignment TyrRII and ADRA2B

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_000673.2
• Gene: ADRA2B / 151
• HGNCID: 282
• Length: 450
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 151/523 - (28%)
• Similarity: 221/523 - (42%)
• Gaps: 126/523 - (24%)

  Fly    79 AVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFG 143
            |....:||.|:.||.||||||||:|.||...|.|:::||..|.||.|.::|.|:...:.|.|.|.
Human    17 AAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFR 81

  Fly   144 WILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITC 208
            ...|:::::||:|.|:.||:.|||||||||.||::.|.|:.||..:|:..: ||.||:.|..|:.
Human    82 RTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCI-ILTVWLIAAVISL 145

  Fly   209 PPYL-----GWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQR 268
            ||.:     |....||.|     |:.||...|::.|::||||.|..:|:.||::| |::..|..|
Human   146 PPLIYKGDQGPQPRGRPQ-----CKLNQEAWYILASSIGSFFAPCLIMILVYLRI-YLIAKRSNR 204

  Fly   269 IVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAK---G 330
                 ...|.......|::.....:|.....:..|                |:.|:.|:|:   |
Human   205 -----RGPRAKGGPGQGESKQPRPDHGGALASAKL----------------PALASVASAREVNG 248

  Fly   331 HQSSVKCSKCSKCSSATGT------------AGAG-----AGAGVVDKTLTFKHQPTFYE----- 373
            |..|....:..:....|||            :|.|     .||...|:....:.:....|
Human   249 HSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQ 313

  Fly   374 LVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALE 438
            .|.||..|:   ||        |.:.. |.|...:.|..  ....||..|
Human   314 AVPVSPASA---CS--------PPLQQ-PQGSRVLATLR--GQVLLGRGV--------------- 349

  Fly   439 TNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIV 503
                                          |:.|.|...        |.:...|:.:....|.:|
Human   350 ------------------------------GAIGGQWWR--------RRAQLTREKRFTFVLAVV 376

  Fly   504 MGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLT 567
            :|..:.||.|||..|.|....|:...:...:|. |.|||:.|.::||.||..:|.|||.||.|:.
Human   377 IGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441

  Fly   568 CRP 570
            |||
Human   442 CRP 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	82/195 (42%)
		TM helix 1	78..101	CDD:410628	12/21 (57%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	6/15 (40%)
		TM helix 5	233..256	CDD:410628	9/22 (41%)
		7tm_GPCRs	<491..563	CDD:475119	26/72 (36%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	10/25 (40%)
ADRA2B	NP_000673.2	7tmA_alpha2B_AR	7..437	CDD:320444	145/514 (28%)
		TM helix 1	14..40	CDD:320444	13/22 (59%)
		TM helix 2	47..73	CDD:320444	10/25 (40%)
		TM helix 3	85..115	CDD:320444	17/29 (59%)
		TM helix 4	127..150	CDD:320444	9/23 (39%)
		TM helix 5	169..198	CDD:320444	12/29 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..229		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..329		21/98 (21%)
		TM helix 6	364..394	CDD:320444	10/29 (34%)
		TM helix 7	405..430	CDD:320444	10/24 (42%)