DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and ADRA2B

DIOPT Version :9

Sequence 1:NP_001262682.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000673.2 Gene:ADRA2B / 151 HGNCID:282 Length:450 Species:Homo sapiens


Alignment Length:523 Identity:151/523 - (28%)
Similarity:221/523 - (42%) Gaps:126/523 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 AVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFG 143
            |....:||.|:.||.||||||||:|.||...|.|:::||..|.||.|.::|.|:...:.|.|.|.
Human    17 AAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFR 81

  Fly   144 WILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITC 208
            ...|:::::||:|.|:.||:.|||||||||.||::.|.|:.||..:|:..: ||.||:.|..|:.
Human    82 RTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCI-ILTVWLIAAVISL 145

  Fly   209 PPYL-----GWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQR 268
            ||.:     |....||.|     |:.||...|::.|::||||.|..:|:.||::| |::..|..|
Human   146 PPLIYKGDQGPQPRGRPQ-----CKLNQEAWYILASSIGSFFAPCLIMILVYLRI-YLIAKRSNR 204

  Fly   269 IVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAK---G 330
                 ...|.......|::.....:|.....:..|                |:.|:.|:|:   |
Human   205 -----RGPRAKGGPGQGESKQPRPDHGGALASAKL----------------PALASVASAREVNG 248

  Fly   331 HQSSVKCSKCSKCSSATGT------------AGAG-----AGAGVVDKTLTFKHQPTFYE----- 373
            |..|....:..:....|||            :|.|     .||...|:....:.:....|     
Human   249 HSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQ 313

  Fly   374 LVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALE 438
            .|.||..|:   ||        |.:.. |.|...:.|..  ....||..|               
Human   314 AVPVSPASA---CS--------PPLQQ-PQGSRVLATLR--GQVLLGRGV--------------- 349

  Fly   439 TNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIV 503
                                          |:.|.|...        |.:...|:.:....|.:|
Human   350 ------------------------------GAIGGQWWR--------RRAQLTREKRFTFVLAVV 376

  Fly   504 MGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLT 567
            :|..:.||.|||..|.|....|:...:...:|. |.|||:.|.::||.||..:|.|||.||.|:.
Human   377 IGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441

  Fly   568 CRP 570
            |||
Human   442 CRP 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_001262682.1 7tm_4 82..>212 CDD:304433 60/129 (47%)
7tm_1 91..>277 CDD:278431 78/190 (41%)
ADRA2BNP_000673.2 7tmA_alpha2B_AR 7..437 CDD:320444 145/514 (28%)
TM helix 1 14..40 CDD:320444 13/22 (59%)
TM helix 2 47..73 CDD:320444 10/25 (40%)
TM helix 3 85..115 CDD:320444 17/29 (59%)
TM helix 4 127..150 CDD:320444 9/23 (39%)
TM helix 5 169..198 CDD:320444 12/29 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..229 4/29 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..329 21/98 (21%)
TM helix 6 364..394 CDD:320444 10/29 (34%)
TM helix 7 405..430 CDD:320444 10/24 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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