Protein Alignment TyrRII and ADRA1A

DIOPT Version :9

• Sequence 1: NP_001262682.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_150646.3
• Gene: ADRA1A / 148
• HGNCID: 277
• Length: 475
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 133/544 - (24%)
• Similarity: 208/544 - (38%)
• Gaps: 218/544 - (40%)

  Fly    73 PKSLAVAVFLVI-----ILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSV 132
            |.:::.|:.|.:     ||..|:||.||||:|...|.|.:||:.:::|||:.|.|:.:.|:|.|.
Human    20 PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84

  Fly   133 VLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMIL 197
            :..:.|.|.||.:.|:||.::|:|.|:.||:.||.||:|||:.|:.||.|......:| .|:.:|
Human    85 IFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRR-GLMALL 148

  Fly   198 VVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVL 262
            .||..:|.|:..|..||.:........  |:.|:..|||:|||:|||::||.::|.:|.:: ||:
Human   149 CVWALSLVISIGPLFGWRQPAPEDETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRV-YVV 210

  Fly   263 TSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAA 327
            ..|..|
Human   211 AKRESR----------------------------------------------------------- 216

  Fly   328 AKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCK 392
              |.:|.:|..|              :.:..|...:..|:.|.
Human   217 --GLKSGLKTDK--------------SDSEQVTLRIHRKNAPA---------------------- 243

  Fly   393 YGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSS 457
             ||       |||....|:..||
Human   244 -GG-------SGMASAKTKTHFS------------------------------------------ 258

  Fly   458 FDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIP 522
                                       :|:....|:.|.||||.||:|..:.||||||   |::|
Human   259 ---------------------------VRLLKFSREKKAAKTLGIVVGCFVLCWLPFF---LVMP 293

  Fly   523 -------FLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF---WRLTCRPICKQK-- 575
                   |.|...|.: ::|   |:|::|..|||.||...:.:|:.||   .|:.|  :|:::
Human   294 IGSFFPDFKPSETVFK-IVF---WLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQC--LCRKQSS 352

  Fly   576 --------RPPN------HLAMFR 585
                    .||:      |..|.|
Human   353 KHALGYTLHPPSQAVEGQHKDMVR 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	54/134 (40%)
		7tm_1	91..>277	CDD:278431	71/185 (38%)
ADRA1A	NP_150646.3	7tm_4	37..341	CDD:304433	122/488 (25%)
		7tm_1	43..326	CDD:278431	114/467 (24%)
		Nuclear localization signal	334..349		5/16 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010