DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and ADRA1D

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000669.1 Gene:ADRA1D / 146 HGNCID:280 Length:572 Species:Homo sapiens


Alignment Length:557 Identity:145/557 - (26%)
Similarity:207/557 - (37%) Gaps:197/557 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 SGNSN-SSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFL-VIILV 87
            ||..| ||.|.    ..||..||||..|.|..|          ||..|  :.:.|.||| ..||:
Human    61 SGEDNRSSAGE----PGSAGAGGDVNGTAAVGG----------LVVSA--QGVGVGVFLAAFILM 109

  Fly    88 TVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWIS 152
            .|.||.||||:|...|.|:||||.|::|||:.|.|:...|:|.|..:.:.|.|.||...||:|.:
Human   110 AVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAA 174

  Fly   153 LDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEV 217
            :|:|.|:.||||||.||:|||:.|...|.|......::.|.::.| :|:.||.::..|.|||.|.
Human   175 VDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILAL-LWVVALVVSVGPLLGWKEP 238

  Fly   218 GRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYD 282
            ......|  |...:..||.|||::.||::|:.|::.:|.::..|..|..:.:......||     
Human   239 VPPDERF--CGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRER----- 296

  Fly   283 VDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSAT 347
                                                                             
Human   297 ----------------------------------------------------------------- 296

  Fly   348 GTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEA 412
                 |..:.||.:                      |||..                      .|
Human   297 -----GKASEVVLR----------------------IHCRG----------------------AA 312

  Fly   413 SFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHH 477
            :.:|                                                    |:||.:|..
Human   313 TGAD----------------------------------------------------GAHGMRSAK 325

  Fly   478 NHHHRMPMRVSTTK--RDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWI 540
            .|..|..:.|...|  |:.|.||||.||:|..:.||.|||....|....|:....|.:.....|:
Human   326 GHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWL 390

  Fly   541 GWVNCAINPFIYAFYNPDFRTAFWR-LTCRPICKQKR 576
            |:.|..:||.||...:.:|:.||.| |.|:  |:::|
Human   391 GYFNSCVNPLIYPCSSREFKRAFLRLLRCQ--CRRRR 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 77/192 (40%)
TM helix 1 78..101 CDD:410628 14/23 (61%)
TM helix 2 110..132 CDD:410628 9/21 (43%)
TM helix 3 148..170 CDD:410628 12/21 (57%)
TM helix 4 194..210 CDD:410628 4/15 (27%)
TM helix 5 233..256 CDD:410628 9/22 (41%)
7tm_GPCRs <491..563 CDD:475119 26/73 (36%)
TM helix 6 497..519 CDD:320098 12/21 (57%)
TM helix 7 531..556 CDD:320098 8/24 (33%)
ADRA1DNP_000669.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..77 8/19 (42%)
7tmA_alpha1D_AR 97..413 CDD:320450 120/489 (25%)
TM helix 1 98..124 CDD:320450 14/25 (56%)
TM helix 2 131..157 CDD:320450 11/25 (44%)
TM helix 3 169..199 CDD:320450 17/29 (59%)
TM helix 4 211..234 CDD:320450 6/23 (26%)
TM helix 5 251..280 CDD:320450 10/28 (36%)
TM helix 6 341..371 CDD:320450 14/29 (48%)
TM helix 7 381..406 CDD:320450 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..488
Blue background indicates that the domain is not in the aligned region.

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