DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and ADRA1D

DIOPT Version :9

Sequence 1:NP_001262682.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000669.1 Gene:ADRA1D / 146 HGNCID:280 Length:572 Species:Homo sapiens


Alignment Length:557 Identity:145/557 - (26%)
Similarity:207/557 - (37%) Gaps:197/557 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 SGNSN-SSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFL-VIILV 87
            ||..| ||.|.    ..||..||||..|.|..|          ||..|  :.:.|.||| ..||:
Human    61 SGEDNRSSAGE----PGSAGAGGDVNGTAAVGG----------LVVSA--QGVGVGVFLAAFILM 109

  Fly    88 TVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWIS 152
            .|.||.||||:|...|.|:||||.|::|||:.|.|:...|:|.|..:.:.|.|.||...||:|.:
Human   110 AVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAA 174

  Fly   153 LDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEV 217
            :|:|.|:.||||||.||:|||:.|...|.|......::.|.::.| :|:.||.::..|.|||.|.
Human   175 VDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILAL-LWVVALVVSVGPLLGWKEP 238

  Fly   218 GRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYD 282
            ......|  |...:..||.|||::.||::|:.|::.:|.::..|..|..:.:......||     
Human   239 VPPDERF--CGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRER----- 296

  Fly   283 VDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSAT 347
                                                                             
Human   297 ----------------------------------------------------------------- 296

  Fly   348 GTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEA 412
                 |..:.||.:                      |||..                      .|
Human   297 -----GKASEVVLR----------------------IHCRG----------------------AA 312

  Fly   413 SFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHH 477
            :.:|                                                    |:||.:|..
Human   313 TGAD----------------------------------------------------GAHGMRSAK 325

  Fly   478 NHHHRMPMRVSTTK--RDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWI 540
            .|..|..:.|...|  |:.|.||||.||:|..:.||.|||....|....|:....|.:.....|:
Human   326 GHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWL 390

  Fly   541 GWVNCAINPFIYAFYNPDFRTAFWR-LTCRPICKQKR 576
            |:.|..:||.||...:.:|:.||.| |.|:  |:::|
Human   391 GYFNSCVNPLIYPCSSREFKRAFLRLLRCQ--CRRRR 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_001262682.1 7tm_4 82..>212 CDD:304433 56/130 (43%)
7tm_1 91..>277 CDD:278431 70/185 (38%)
ADRA1DNP_000669.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..77 8/19 (42%)
7tmA_alpha1D_AR 97..413 CDD:320450 120/489 (25%)
TM helix 1 98..124 CDD:320450 14/25 (56%)
TM helix 2 131..157 CDD:320450 11/25 (44%)
TM helix 3 169..199 CDD:320450 17/29 (59%)
TM helix 4 211..234 CDD:320450 6/23 (26%)
TM helix 5 251..280 CDD:320450 10/28 (36%)
TM helix 6 341..371 CDD:320450 14/29 (48%)
TM helix 7 381..406 CDD:320450 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..488
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 263 1.000 Inparanoid score I3089
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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