DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and ADORA2B

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000667.1 Gene:ADORA2B / 136 HGNCID:264 Length:332 Species:Homo sapiens


Alignment Length:341 Identity:89/341 - (26%)
Similarity:134/341 - (39%) Gaps:75/341 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 SLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVL---YI 136
            :|.||:.|||..::|.||.||..||.|...|:|.||.|:::||..|..||...:|.::.:   :.
Human     8 ALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFC 72

  Fly   137 TGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWI 201
            |..:...::.|.:     ::|...||.||.|:::|||||:..||.|.......| |..:|.|:|:
Human    73 TDFYGCLFLACFV-----LVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTR-ARGVIAVLWV 131

  Fly   202 TALSITCPPYLGWYE--------------VGRHQAEFVDCRYNQ--NKGYVV-FSAMGSFFIPLT 249
            .|..|...|:|||..              ........|.|.:..  ...|:| |:..|....||.
Human   132 LAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLL 196

  Fly   250 VMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTK----------WLP 304
            :||.:|:||..|...:.||.....:|..|...::            |...:.          |||
Human   197 IMLVIYIKIFLVACRQLQRTELMDHSRTTLQREI------------HAAKSLAMIVGIFALCWLP 249

  Fly   305 ---------------NRKSRWRF---------NSLHDPPPSAATNAAAK--GHQSSVKCSKC-SK 342
                           ..|.:|..         ||:.:|...|..|...:  .|:...:...| :.
Human   250 VHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQAD 314

  Fly   343 CSSATGTAGAGAGAGV 358
            ..|..|.||.....||
Human   315 VKSGNGQAGVQPALGV 330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 67/211 (32%)
TM helix 1 78..101 CDD:410628 12/22 (55%)
TM helix 2 110..132 CDD:410628 8/21 (38%)
TM helix 3 148..170 CDD:410628 6/21 (29%)
TM helix 4 194..210 CDD:410628 5/15 (33%)
TM helix 5 233..256 CDD:410628 8/23 (35%)
7tm_GPCRs <491..563 CDD:475119
TM helix 6 497..519 CDD:320098
TM helix 7 531..556 CDD:320098
ADORA2BNP_000667.1 7tmA_Adenosine_R_A2B 8..301 CDD:320197 81/310 (26%)
TM helix 1 9..35 CDD:320197 13/25 (52%)
TM helix 2 42..69 CDD:320197 9/26 (35%)
TM helix 3 78..108 CDD:320197 12/34 (35%)
TM helix 4 122..140 CDD:320197 6/17 (35%)
TM helix 5 179..209 CDD:320197 11/29 (38%)
TM helix 6 227..257 CDD:320197 4/41 (10%)
TM helix 7 269..294 CDD:320197 5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

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