DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and ADORA2A

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000666.2 Gene:ADORA2A / 135 HGNCID:263 Length:412 Species:Homo sapiens


Alignment Length:546 Identity:98/546 - (17%)
Similarity:162/546 - (29%) Gaps:261/546 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 VPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVG 124
            :|.|.|         |:.:.|.|.|.::.::||.||..||.....|:.|||.||::||..|..||
Human     1 MPIMGS---------SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVG 56

  Fly   125 TCVMPPSVVL---YITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKR 186
            ...:|.::.:   :........:|.|.:     ::|...||.||.||::|||:|:..||.|:...
Human    57 VLAIPFAITISTGFCAACHGCLFIACFV-----LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLV 116

  Fly   187 RSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKG----------------- 234
            ...| |..:|.:.|:.:.:|...|.|||...|:.:.     ..|.::|                 
Human   117 TGTR-AKGIIAICWVLSFAIGLTPMLGWNNCGQPKE-----GKNHSQGCGEGQVACLFEDVVPMN 175

  Fly   235 YVV-FSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCT 298
            |:| |:......:||.:||.||::|  .|.:|||                     :.:.|     
Human   176 YMVYFNFFACVLVPLLLMLGVYLRI--FLAARRQ---------------------LKQME----- 212

  Fly   299 PTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTL 363
             ::.||..::|                                                      
Human   213 -SQPLPGERAR------------------------------------------------------ 222

  Fly   364 TFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTT 428
                                                                             
Human   223 ----------------------------------------------------------------- 222

  Fly   429 TTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRD 493
                                                                       ||.:::
Human   223 -----------------------------------------------------------STLQKE 228

  Fly   494 SKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWV-------NCAINPFI 551
            ...||:|.|::|....||||..:......|.|      |......|:.::       |..:||||
Human   229 VHAAKSLAIIVGLFALCWLPLHIINCFTFFCP------DCSHAPLWLMYLAIVLSHTNSVVNPFI 287

  Fly   552 YAFYNPDFRTAFWRLTCRPICKQKRP 577
            ||:...:||..|.::....:.:|:.|
Human   288 YAYRIREFRQTFRKIIRSHVLRQQEP 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 63/212 (30%)
TM helix 1 78..101 CDD:410628 9/22 (41%)
TM helix 2 110..132 CDD:410628 9/21 (43%)
TM helix 3 148..170 CDD:410628 7/21 (33%)
TM helix 4 194..210 CDD:410628 3/15 (20%)
TM helix 5 233..256 CDD:410628 9/40 (23%)
7tm_GPCRs <491..563 CDD:475119 22/78 (28%)
TM helix 6 497..519 CDD:320098 9/21 (43%)
TM helix 7 531..556 CDD:320098 9/31 (29%)
ADORA2ANP_000666.2 7tmA_Adenosine_R_A2A 7..299 CDD:320196 92/515 (18%)
TM helix 1 8..34 CDD:320196 9/25 (36%)
TM helix 2 41..68 CDD:320196 10/26 (38%)
TM helix 3 77..107 CDD:320196 13/34 (38%)
TM helix 4 121..139 CDD:320196 4/17 (24%)
TM helix 5 174..204 CDD:320196 11/31 (35%)
TM helix 6 226..256 CDD:320196 9/29 (31%)
TM helix 7 267..292 CDD:320196 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..412
Blue background indicates that the domain is not in the aligned region.

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