Protein Alignment TyrRII and Drd4

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_031904.1
• Gene: Drd4 / 13491
• MGIID: 94926
• Length: 387
• Species: Mus musculus
• Alignment Length: 554
• Identity: 148/554 - (26%)
• Similarity: 219/554 - (39%)
• Gaps: 175/554 - (31%)

  Fly    26 GNSNSS-DGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTV 89
            |||::: ||.||     |..|.:.:.||||.|..|..::              |...|:|.|| :
Mouse     2 GNSSATEDGGLL-----AGRGPESLGTGAGLGGAGAAAL--------------VGGVLLIGLV-L 46

  Fly    90 VGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYIT-GTWRFGWILCDIWISL 153
            .||:||.::|.:.|.|:|.||.|:::||..|.|:...|:|..|...:. |.|.....|||..:::
Mouse    47 AGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAM 111

  Fly   154 DILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEV- 217
            |::||:.||.:|||||:||::|||.||.|:::.:.:   ||:|...|:.:.::..|...|..:|
Mouse   112 DVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQ---LLLIAATWLLSAAVASPVVCGLNDVP 173

  Fly   218 GRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYD 282
            ||..|  |.|.  :|:.|||:|::.|||:|..:||.:|
Mouse   174 GRDPA--VCCL--ENRDYVVYSSVCSFFLPCPLMLLLY--------------------------- 207

  Fly   283 VDGDNFISESEHYHCTPTKWLPNR-KSRW---RFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKC 343
                               |...| ..||   |...||...|...
Mouse   208 -------------------WATFRGLRRWEAARHTKLHSRAPRRP-------------------- 233

  Fly   344 SSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYV 408
                    :|.|..|.|.|     |..|:.                .|....|.:.::||.....
Mouse   234 --------SGPGPPVSDPT-----QGPFFP----------------DCPPPLPSLRTSPSDSSRP 269

  Fly   409 GTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQ 473
            .:|.| ...|..|                    .|.|:|...|..:.||
Mouse   270 ESELS-QRPCSPG--------------------CLLADAALPQPPEPSS---------------- 297

  Fly   474 QSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFT 538
                    |.......|.|:.|..:.|.:|:|..:.||.||||.::.....|...|...|:...|
Mouse   298 --------RRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVT 354

  Fly   539 WIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPIC 572
            |:|:||.|:||.||..:|.:||:.| |.|.|..|
Mouse   355 WLGYVNSALNPIIYTIFNAEFRSVF-RKTLRLRC 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	70/193 (36%)
		TM helix 1	78..101	CDD:410628	10/22 (45%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	10/22 (45%)
		7tm_GPCRs	<491..563	CDD:475119	27/71 (38%)
		TM helix 6	497..519	CDD:320098	9/21 (43%)
		TM helix 7	531..556	CDD:320098	11/24 (46%)
Drd4	NP_031904.1	7tm_GPCRs	42..379	CDD:475119	126/484 (26%)
		TM helix 2	67..89	CDD:410628	8/21 (38%)
		TM helix 3	106..128	CDD:410628	10/21 (48%)
		TM helix 4	149..165	CDD:410628	3/15 (20%)
		TM helix 5	185..208	CDD:410628	11/68 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..247		9/55 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..306		5/42 (12%)
		TM helix 6	313..335	CDD:410628	9/21 (43%)
		TM helix 7	347..372	CDD:410628	11/24 (46%)