DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TyrRII and Drd2

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_034207.2 Gene:Drd2 / 13489 MGIID:94924 Length:444 Species:Mus musculus


Alignment Length:552 Identity:145/552 - (26%)
Similarity:218/552 - (39%) Gaps:178/552 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 GKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITD 120
            ||...|..|.|.:           :..::|.:.|.||.||.:||...:.|:|.||..:::||:.|
Mouse    27 GKPDRPHYNYYAM-----------LLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVAD 80

  Fly   121 WLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKK 185
            .||.|.|||..|.|.:.|.|:|..|.|||:::||:::|:.|||:|||||:|||.||..|:.|:.:
Mouse    81 LLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTR 145

  Fly   186 RRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTV 250
            ..|||...:||.:||:.:.:|:||...|.....:::....      |..:||:|::.||::|..|
Mouse   146 YSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIA------NPAFVVYSSIVSFYVPFIV 204

  Fly   251 MLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSL 315
            .|.||:||..||..||:|:                             .||    |.||....:|
Mouse   205 TLLVYIKIYIVLRKRRKRV-----------------------------NTK----RSSRAFRANL 236

  Fly   316 HDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRL 380
            ..|.....|      |...:|.  |:....:.|:.                  |.....::.:|.
Mouse   237 KTPLKGNCT------HPEDMKL--CTVIMKSNGSF------------------PVNRRRMDAARR 275

  Fly   381 SSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEA 445
            :..:....:|..       |.|....|.....|                                
Mouse   276 AQELEMEMLSST-------SPPERTRYSPIPPS-------------------------------- 301

  Fly   446 EAKQKQQQQRSSFDHHH---PHAHHHGSHGQ-----QSHHNHHHR-------------------- 482
                          ||.   |...|||.|..     :...|.|.:                    
Mouse   302 --------------HHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKT 352

  Fly   483 ------MPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLL-------IPFLPRPAVLEDLM 534
                  |..|..:.:::.|..:.|.||:|..|.||||||:.::|       ||    |.    |.
Mouse   353 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIP----PV----LY 409

  Fly   535 FGFTWIGWVNCAINPFIYAFYNPDFRTAFWRL 566
            ..|||:|:||.|:||.||..:|.:||.||.::
Mouse   410 SAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKI 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 77/191 (40%)
TM helix 1 78..101 CDD:410628 8/22 (36%)
TM helix 2 110..132 CDD:410628 10/21 (48%)
TM helix 3 148..170 CDD:410628 12/21 (57%)
TM helix 4 194..210 CDD:410628 6/15 (40%)
TM helix 5 233..256 CDD:410628 9/22 (41%)
7tm_GPCRs <491..563 CDD:475119 31/78 (40%)
TM helix 6 497..519 CDD:320098 11/21 (52%)
TM helix 7 531..556 CDD:320098 12/24 (50%)
Drd2NP_034207.2 7tmA_D2_dopamine_R 35..438 CDD:320435 140/539 (26%)
TM helix 1 36..62 CDD:320435 9/36 (25%)
TM helix 2 69..92 CDD:320435 11/22 (50%)
TM helix 3 107..137 CDD:320435 18/29 (62%)
TM helix 4 152..170 CDD:320435 6/17 (35%)
TM helix 5 186..211 CDD:320435 11/24 (46%)
Interaction with PPP1R9B. /evidence=ECO:0000250 211..374 38/274 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..329 12/99 (12%)
TM helix 6 367..397 CDD:320435 12/29 (41%)
TM helix 7 406..431 CDD:320435 13/28 (46%)

Return to query results.
Submit another query.