Protein Alignment TyrRII and Drd1

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_034206.1
• Gene: Drd1 / 13488
• MGIID: 99578
• Length: 446
• Species: Mus musculus
• Alignment Length: 517
• Identity: 130/517 - (25%)
• Similarity: 193/517 - (37%)
• Gaps: 208/517 - (40%)

  Fly    76 LAVAVFL-VIILVTVVGNTLVILAVLTTRRLRT-VTNCFVMNLAITDWLVGTCVMPPSVVLYITG 138
            :..|.|| ::||.|::|||||..||:..|.||: |||.||::||::|.||...|||...|..|.|
Mouse    23 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 87

  Fly   139 TWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITA 203
            .|.|| ..|:||::.||:..:.|||:||.||:|||.|::.|..|.:|...| .|.::|.|.|..:
Mouse    88 FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPK-AAFILISVAWTLS 150

  Fly   204 LSIT-CPPYLGWYE-----------VGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYV 256
            :.|: .|..|.|::           .....||..:|....::.|.:.|::.||:||:.:|:..|.
Mouse   151 VLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYT 215

  Fly   257 KIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPS 321
            .|..:...:.:||                                                   |
Mouse   216 SIYRIAQKQIRRI---------------------------------------------------S 229

  Fly   322 AATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHC 386
            |...||                                                        :|
Mouse   230 ALERAA--------------------------------------------------------VH- 237

  Fly   387 SAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQ 451
             |.:|:                                  |||...|.|          |..|.:
Mouse   238 -AKNCQ----------------------------------TTTGNGNPV----------ECSQSE 257

  Fly   452 QQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFV 516
            ...:.||                                ||::|..|||:::||..:.||||||:
Mouse   258 SSFKMSF--------------------------------KRETKVLKTLSVIMGVFVCCWLPFFI 290

  Fly   517 YYLLIPFL----PRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLT-CRPIC 572
            ...::||.    .:|..::.:.|. |.|.||.|.::||.|||| |.||:.||..|. |..:|
Mouse   291 SNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAF-NADFQKAFSTLLGCYRLC 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	76/205 (37%)
		TM helix 1	78..101	CDD:410628	13/23 (57%)
		TM helix 2	110..132	CDD:410628	11/21 (52%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	4/16 (25%)
		TM helix 5	233..256	CDD:410628	7/22 (32%)
		7tm_GPCRs	<491..563	CDD:475119	32/76 (42%)
		TM helix 6	497..519	CDD:320098	11/21 (52%)
		TM helix 7	531..556	CDD:320098	12/25 (48%)
Drd1	NP_034206.1	7tm_GPCRs	22..341	CDD:475119	125/505 (25%)
		TM helix 1	25..49	CDD:410628	13/23 (57%)
		TM helix 2	59..81	CDD:410628	11/21 (52%)
		TM helix 3	96..118	CDD:410628	10/21 (48%)
		TM helix 4	141..157	CDD:410628	4/15 (27%)
		TM helix 5	192..215	CDD:410628	7/22 (32%)
		TM helix 6	271..293	CDD:410628	11/21 (52%)
		TM helix 7	310..335	CDD:410628	12/25 (48%)