Protein Alignment TyrRII and TAAR9

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 102/492 - (20%)
• Similarity: 153/492 - (31%)
• Gaps: 217/492 - (44%)

  Fly    73 PKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYIT 137
            |:|:..||.....::...||.||::|:|..::|.|.||..:.:||..|:|||..|||.|.|..:.
Human    31 PRSILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVE 95

  Fly   138 GTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWIT 202
            ..|.||...|......|...|..|:..||.||:|||:|||.||||..| .:..::.:.|::.|..
Human    96 SCWYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTK-FTVSVSGICIVLSWFF 159

  Fly   203 ALSITCPP-YLGWYEVGRHQAEFV-----DCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYV 261
            :::.:... |.|..|.|..:....     .|:...|:.:|:...: .||||...|:::|.||
Human   160 SVTYSFSIFYTGANEEGIEELVVALTCVGGCQAPLNQNWVLLCFL-LFFIPNVAMVFIYSKI--- 220

  Fly   262 LTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNA 326
                                                                             
Human   221 ----------------------------------------------------------------- 220

  Fly   327 AAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISC 391
                                               .|..|||.
Human   221 -----------------------------------FLVAKHQA---------------------- 228

  Fly   392 KYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRS 456
                                                             .|:|:.|.|
Human   229 -------------------------------------------------RKIESTASQ------- 237

  Fly   457 SFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLL- 520
                           .|.|..::..|:      .||:.|.||||.|.|...:..|||:.|..::
Human   238 ---------------AQSSSESYKERV------AKRERKAAKTLGIAMAAFLVSWLPYLVDAVID 281

  Fly   521 --IPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFY 555
              :.|:..|.|.|.|:    |..:.|.|:||.||||:
Human   282 AYMNFITPPYVYEILV----WCVYYNSAMNPLIYAFF 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	62/197 (31%)
		TM helix 1	78..101	CDD:410628	7/22 (32%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	6/21 (29%)
		TM helix 4	194..210	CDD:410628	2/15 (13%)
		TM helix 5	233..256	CDD:410628	6/22 (27%)
		7tm_GPCRs	<491..563	CDD:475119	27/68 (40%)
		TM helix 6	497..519	CDD:320098	10/21 (48%)
		TM helix 7	531..556	CDD:320098	11/25 (44%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	101/490 (21%)
		TM helix 1	34..60	CDD:320439	8/25 (32%)
		TM helix 2	67..93	CDD:320439	13/25 (52%)
		TM helix 3	105..135	CDD:320439	12/29 (41%)
		TM helix 4	147..170	CDD:320439	2/22 (9%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		2/12 (17%)
		TM helix 5	194..223	CDD:320439	10/132 (8%)
		TM helix 6	251..281	CDD:320439	13/29 (45%)
		TM helix 7	290..315	CDD:320439	13/29 (45%)