Protein Alignment TyrRII and Dop1R1

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_061506303.1
• Gene: Dop1R1 / 1275919
• VectorBaseID: AGAMI1_010805
• Length: 445
• Species: Anopheles gambiae
• Alignment Length: 583
• Identity: 133/583 - (22%)
• Similarity: 212/583 - (36%)
• Gaps: 213/583 - (36%)

  Fly    17 LSTALTVAS----GNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVP-----SMNSYLVSMAW 72
            ||:..||.|    ||..|.:      ||..:..|....|||.:| .|:|     ..:...|.:..
Mosquito    14 LSSTSTVVSATTIGNLTSVN------QTDGSGDGSGSGTGASSG-TGIPGGPGEDTDDDDVDVLS 71

  Fly    73 PKSLA-VAVFL-VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLY 135
            |.|:: :.||| ::|.::|.||.||.:|:.|.|.||.:.|.|:.:|||.|..|.:.||..:.|..
Mosquito    72 PLSMSFLGVFLSIVIFLSVAGNILVCIAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVND 136

  Fly   136 ITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVW 200
            :.|.|.||...||.|::.|::..:.|||:|||||||||:.:..||.|. :..::|:|:..|.|:|
Mosquito   137 LLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISLDRYIHIKDPLRYG-RWVTRRVAIGTIAVIW 200

  Fly   201 ITALSITCPPY-LGWYEVGRHQAE---------FVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVY 255
            :.|..::..|. |..:...|.:.:         :..|..:....|.|.|:..||::|..||:.:|
Mosquito   201 LLAALVSFVPISLDLHRDKRDKTDTSLKINGIKYETCALDLTPTYAVVSSCISFYVPCIVMIGIY 265

  Fly   256 VKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPP 320
            .:: |....:..:.:|                          ..|:  |...|..|:.|:..|
Mosquito   266 CRL-YCYAQKHVKSIR--------------------------AVTR--PGEISEKRYRSIRRP-- 299

  Fly   321 SAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIH 385
                    |..::.:|                                           |..|.|
Mosquito   300 --------KSSKNKLK-------------------------------------------LRQLAH 313

  Fly   386 CSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQK 450
            .::
Mosquito   314 TAS-------------------------------------------------------------- 316

  Fly   451 QQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFF 515
                                            .|..||    |.|.|.|:.::||..:.||:|||
Mosquito   317 --------------------------------SPYHVS----DHKAAITVGVIMGVFLICWVPFF 345

  Fly   516 VYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWR-LTCRP--ICKQK 575
            ...::..|. :..:.:......:|:|:.|.|.||.||:.:|.:||.||.| ||.|.  .|.|:
Mosquito   346 CVNIIAAFC-KTCIGQQTFKVLSWLGYSNSAFNPIIYSIFNTEFREAFKRILTSRSSWCCGQE 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	67/202 (33%)
		TM helix 1	78..101	CDD:410628	10/23 (43%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	8/22 (36%)
		7tm_GPCRs	<491..563	CDD:475119	23/71 (32%)
		TM helix 6	497..519	CDD:320098	9/21 (43%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
Dop1R1	XP_061506303.1	None