Protein Alignment TyrRII and Oct-TyrR

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_061506991.1
• Gene: Oct-TyrR / 1273444
• VectorBaseID: AGAMI1_002266
• Length: 644
• Species: Anopheles gambiae
• Alignment Length: 669
• Identity: 182/669 - (27%)
• Similarity: 280/669 - (41%)
• Gaps: 177/669 - (26%)

  Fly     4 LEHPDAMLPYSKLLSTALTVASGNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKL--GVPSMNSY 66
            |.| :..:|...|.....|:..    .|:|.||        |.:..|.|:...:|  |.|..:..
Mosquito    42 LRH-EGSIPAVSLAGLTATLGL----DSNGELL--------GANYGANGSDLSELLDGCPKPDDT 93

  Fly    67 L------VSMAWPKSLAVAVFLV---IILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWL 122
            |      :.:|.|:..|:...|:   ||::|:|||.||||:|.|.:.||.|.|.|:::||:.|..
Mosquito    94 LYPTMFGIDLAVPQWEAIGTALILTLIIIITIVGNILVILSVFTYKPLRIVQNFFIVSLAVADLT 158

  Fly   123 VGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRR 187
            |...|:|.:|...:.|.|.||..:|.:|::.|:|.|:.|||:||||:||||.|:|.|:.|::||.
Mosquito   159 VAILVLPLNVAYSLLGRWEFGIHVCKMWLTSDVLCCTASILNLCAIALDRYWAITDPINYAQKRT 223

  Fly   188 SKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVML 252
            .:|: |.:|..||:.:|.|:.||.:||.:.....:....|:...|:|||::|::|||||||.:|.
Mosquito   224 LERV-LALIAGVWVLSLVISSPPLIGWNDWPEEFSSEFPCQLTSNQGYVIYSSLGSFFIPLAIMT 287

  Fly   253 YVYVKIGYVLTSRRQR------------------IVRDAYSERTADY------------------ 281
            .||::| |:.|.||.|                  :..:...|.|..:
Mosquito   288 IVYIEI-YIATRRRLRERAQASKINTLASRSIGMVAGNGEKELTTTHHQQQQQQQQHQHHHQSHH 351

  Fly   282 -------DVDGDNFISE-SEHYHCTPT---------KWLPNRKSRWRFNSL-------------- 315
                   ..|.::..|| :.|...|.|         ...||:|...||...
Mosquito   352 HQDGHAIQHDQESISSETNNHNEQTDTGSGGPVLAGSGKPNKKGHLRFGGYLGRALGGAAGRHRK 416

  Fly   316 ---H-----DPPPSAATN------AAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFK 366
               |     |.|.....:      ||:..||........:...|.:|.:|.|.|...:|..
Mosquito   417 KQHHRKRPGDGPAEEGEDGRPHRLAASALHQREDDSVTDNPDHSGSGDSGGGVGKAPLDAA---- 477

  Fly   367 HQPTFYELVEVSRLSSLIHCSAI-----SCKY------GGPCMHSTPSGMHY---VGTEASFSDT 417
                              |.||:     :|..      |.|...:..|..|:   ||...|.::.
Mosquito   478 ------------------HPSALLPPTGNCDMTGGSATGEPAPRNGASNNHHQREVGFHESTAEL 524

  Fly   418 CLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHR 482
            .:....:..||             :|....||                    |..:....|....
Mosquito   525 MVVAAAAPPTT-------------RLGGRLKQ--------------------SFRKPGGINQFIE 556

  Fly   483 MPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAI 547
            ...::|.:| :.:.|:||.|:||..:.||||||:.|:::||.|.......|:...||:|::|.|:
Mosquito   557 EKQKISLSK-ERRAARTLGIIMGVFVVCWLPFFLMYVILPFCPSCCPTNKLINFITWLGYINSAL 620

  Fly   548 NPFIYAFYNPDFRTAFWRL 566
            ||.||..:|.|:|.||.||
Mosquito   621 NPIIYTIFNLDYRRAFKRL 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	84/212 (40%)
		TM helix 1	78..101	CDD:410628	12/25 (48%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	5/15 (33%)
		TM helix 5	233..256	CDD:410628	13/22 (59%)
		7tm_GPCRs	<491..563	CDD:475119	30/71 (42%)
		TM helix 6	497..519	CDD:320098	12/21 (57%)
		TM helix 7	531..556	CDD:320098	10/24 (42%)
Oct-TyrR	XP_061506991.1	None