Protein Alignment TyrRII and LOC1269968

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_061499186.1
• Gene: LOC1269968 / 1269968
• VectorBaseID: AGAMI1_010361
• Length: 587
• Species: Anopheles gambiae
• Alignment Length: 665
• Identity: 181/665 - (27%)
• Similarity: 257/665 - (38%)
• Gaps: 211/665 - (31%)

  Fly    12 PYSKLLSTALTVASG-------NSNSSDGTLLLIQTSAAPGGDVMATG------------AGAGK 57
            |....|:|||:.|:.       :|.|.|..|         ..||.:.|            |....
Mosquito     9 PRPPSLATALSKANDVYDYIFIDSGSPDSYL---------SADVGSIGNETFFNESANAFANTTD 64

  Fly    58 LG-VP-SMN-------SYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFV 113
            || || |:|       :.::.||    :...|..::|||||:||..||.|::..|.|:.|.|..|
Mosquito    65 LGPVPASINGTADEPLADVIVMA----ITSLVLGLMILVTVIGNVFVIAAIILERNLQNVANYLV 125

  Fly   114 MNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQ 178
            .:||:.|..|...|||...|..|:..|..|..|||||.|.|:|.|:.|||.|.||:.|||.|||.
Mosquito   126 ASLAVADLFVACLVMPLGAVYEISRGWILGPELCDIWTSCDVLCCTASILHLVAIATDRYWAVTN 190

  Fly   179 PLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQ-AEFVDCRYNQNKGYVVFSAMG 242
             :.|...|.|:|: ..||.:||..::.::..|..||.:....| .|...|..:||..|.||:...
Mosquito   191 -IDYIHSRTSRRV-FTMIFLVWFASVIVSLAPQFGWKDPEYLQRIEQQKCMVSQNIAYQVFATCC 253

  Fly   243 SFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPT----KWL 303
            :|::||.|:|.:|.||   ..:.|:||.|                   .......||.    :..
Mosquito   254 TFYVPLFVILVLYWKI---YQTARRRIHR-------------------RGPKIPATPNSSNQEET 296

  Fly   304 PNRKSRWRF----------------------------NSLHDPPPSAATNAAAKG---------- 330
            |..||:.||                            |::.|...|.|..|..||
Mosquito   297 PKPKSKIRFHLKKKFTNPTKSAVSSLGLVEGNSTNTVNTVEDTEDSTANAADRKGLETTFSGDEG 361

  Fly   331 ------------------HQSSVKCSKCSKCSS-----ATGTAG----AGAGAGVVDKTLTFKHQ 368
                              ||...:.:.||:.::     .||:||    :|.|..:...|
Mosquito   362 NGTPLGNNQIPTVSYEVTHQQLAQAAGCSESNNNNNPGRTGSAGKTSPSGNGGTLPGST------ 420

  Fly   369 PTFYELVEVSRLSSLI------HCSAISCKY--GGPCMHSTP----SGMHYVGTEASFSDTCLGG 421
               |.:..|...|.|:      |.:|.:.|.  |.|..|.||    ||:...|          ||
Mosquito   421 ---YPVQAVHASSPLLPPQHQHHNAATAAKQPAGTPTAHLTPGSAGSGLQGAG----------GG 472

  Fly   422 NVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMR 486
            :..|..:|........:..|.|||
Mosquito   473 STLNIASTPNPQAQVSKRKETLEA----------------------------------------- 496

  Fly   487 VSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFI 551
                ||:.|.||||.|:.|..:.||||||:..||:|.....::.:.:...|.|:|:.|..:||.|
Mosquito   497 ----KRERKAAKTLAIITGAFVVCWLPFFLTALLLPLCESCSINDTVASLFLWLGYFNSTLNPVI 557

  Fly   552 YAFYNPDFRTAFWRL 566
            |..::|:||.||.|:
Mosquito   558 YTIFSPEFRQAFKRI 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	77/192 (40%)
		TM helix 1	78..101	CDD:410628	11/22 (50%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	13/21 (62%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	8/22 (36%)
		7tm_GPCRs	<491..563	CDD:475119	29/71 (41%)
		TM helix 6	497..519	CDD:320098	12/21 (57%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
LOC1269968	XP_061499186.1	None