Protein Alignment TyrRII and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_061500179.1
• Gene: 5-HT2A / 1269329
• VectorBaseID: AGAMI1_010455
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 534
• Identity: 149/534 - (27%)
• Similarity: 223/534 - (41%)
• Gaps: 111/534 - (20%)

  Fly    81 FLVIILVTV---VGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRF 142
            ||.:||...   :||.||.|||...|:|:.|||.|:::|||.|.||...|||...:....|.|.|
Mosquito   315 FLFVILFIFAGGLGNILVCLAVALDRKLQNVTNYFLLSLAIADLLVSLFVMPLGAIPGFLGYWPF 379

  Fly   143 GWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITAL--- 204
            |...|:|:::.|:|.||.|||.:|.|||.|||.:..||. |:...:|||..:.|.:||:.|:
Mosquito   380 GVTWCNIYVTCDVLACSASILHMCFISLGRYLGIRNPLG-SRHHSTKRLTGIKIALVWLLAMLVS 443

  Fly   205 -SITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQR 268
             |||   .||............:|..| |:.:.||.::.:|:||:.:|:     :.|.||.:..|
Mosquito   444 SSIT---VLGMINQNNIMPGPNECVIN-NRAFFVFGSLVAFYIPMVMMV-----VTYALTVQLLR 499

  Fly   269 IVRDAYSERTADYDVDGDNF------ISESEHYH-------CTPTKWLPNRKSRWRFN-----SL 315
                 ...|..:...:|:.|      ::.|:|.:       .|..|.:..||.....|     ..
Mosquito   500 -----KKARFLEQHPEGELFRRLGGRLASSKHSNNSQSDGSSTSNKAVEMRKFTVNNNKQPAYGQ 559

  Fly   316 HDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTA--GAGAGAGVVDKTLTFKHQPTFYELVEVS 378
            ||..|.::..:.|.||             ||....  |..||.|.:|                 |
Mosquito   560 HDSSPPSSLPSVAAGH-------------SALPWRWHGTTAGTGKMD-----------------S 594

  Fly   379 RLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTT-----TTTTNTVALE 438
            |:||:                           :.|.|...||.:...|.|     :.|......:
Mosquito   595 RMSSI---------------------------KGSMSHPHLGYSNGGNRTMAGKRSRTVCDQGTQ 632

  Fly   439 TNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIV 503
            |.:.:|.|.:   :|:..||..|.........:..........|..:..:....:.|..|.|.:|
Mosquito   633 TPDSIERETR---RQKFCSFRIHLNSVPTPAINFNLKFLGSKKRTNLSANAVATEQKATKVLGLV 694

  Fly   504 MGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWR-LT 567
            ....:.||.|||:..::....|...|.|.::....|:|:|:..|||.||..:|..||.||.| |.
Mosquito   695 FFTFVFCWAPFFILNIIFAAWPEAKVPERIVSICLWLGYVSSTINPIIYTIFNKTFRAAFIRLLR 759

  Fly   568 CRPICKQK-RPPNH 580
            ||  |::. |||.:
Mosquito   760 CR--CERSGRPPRY 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	74/195 (38%)
		TM helix 1	78..101	CDD:410628	11/22 (50%)
		TM helix 2	110..132	CDD:410628	11/21 (52%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	7/19 (37%)
		TM helix 5	233..256	CDD:410628	6/22 (27%)
		7tm_GPCRs	<491..563	CDD:475119	23/71 (32%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	9/24 (38%)
5-HT2A	XP_061500179.1	None