Protein Alignment TyrRII and Chrm3

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_150372.1
• Gene: Chrm3 / 12671
• MGIID: 88398
• Length: 589
• Species: Mus musculus
• Alignment Length: 642
• Identity: 153/642 - (23%)
• Similarity: 250/642 - (38%)
• Gaps: 173/642 - (26%)

  Fly     8 DAMLP---YSKLLSTALTVASGNSNSSDGTLLLIQTSAAP-GGDVMATGAGAGKLGVPSMNSYLV 68
            :|.||   .|:|.|..::..|||.:|:|       ||:.| ||..:
Mouse    26 EAGLPLGTVSQLDSYNISQTSGNFSSND-------TSSDPLGGHTI------------------- 64

  Fly    69 SMAWPKSLAVAVFLV--IILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPS 131
               |  .:....||.  :.|||::||.|||:|....::|:||.|.|:::||..|.::|...|...
Mouse    65 ---W--QVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLF 124

  Fly   132 VVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMI 196
            ....|...|..|.:.||:|:|:|.:..:.|:::|..||.|||.::|:||||..||.:|| |.:||
Mouse   125 TTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKR-AGVMI 188

  Fly   197 LVVWITALSITCPPYLGW-YEVGRHQAEFVDCRYNQNKGYVVF---------SAMGSFFIPLTVM 251
            .:.|:.:..:..|..|.| |.||:......:|       ::.|         :|:.:|::|:|:|
Mouse   189 GLAWVISFVLWAPAILFWQYFVGKRTVPPGEC-------FIQFLSEPTITFGTAIAAFYMPVTIM 246

  Fly   252 LYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFI---------SESE-------------- 293
            ..:|.:| |..|.:|.:.:....:..|   :.:.:||:         |..|
Mouse   247 TILYWRI-YKETEKRTKELAGLQASGT---EAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKY 307

  Fly   294 ---HYHCTPTKWLPNRK---------SRWRFNSLHDPPPSAATNAAA------------------ 328
               |:..|...|.|:.:         ..|..|   |...|...:|::
Mouse   308 GGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNN---DAAASLENSASSDEEDIGSETRAIYSIVLK 369

  Fly   329 -KGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTL-TFKHQPTFYELVEVSRLSSLIHCSAISC 391
             .||.:.:..:|.....:..          |.||.| |...:...::|.....:....:|.....
Mouse   370 LPGHSTILNSTKLPSSDNLQ----------VPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFS 424

  Fly   392 KYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRS 456
            |        .|..:......|..|||        |::...| |.||..:.|....||:...:.||
Mouse   425 K--------LPIQLESAVDTAKTSDT--------NSSVDKT-TAALPLSFKEATLAKRFALKTRS 472

  Fly   457 SFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLI 521
            .....                       .|:|..| :.|.|:||:.::...|..|.|:.:..|:.
Mouse   473 QITKR-----------------------KRMSLIK-EKKAAQTLSAILLAFIITWTPYNIMVLVN 513

  Fly   522 PFLPR--PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKR 576
            .|...  |....:|.:   |:.::|..:||..||..|..|||.|..|......|:||
Mouse   514 TFCDSCIPKTYWNLGY---WLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKR 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	67/203 (33%)
		TM helix 1	78..101	CDD:410628	11/24 (46%)
		TM helix 2	110..132	CDD:410628	7/21 (33%)
		TM helix 3	148..170	CDD:410628	7/21 (33%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	6/31 (19%)
		7tm_GPCRs	<491..563	CDD:475119	22/73 (30%)
		TM helix 6	497..519	CDD:320098	6/21 (29%)
		TM helix 7	531..556	CDD:320098	7/24 (29%)
Chrm3	NP_150372.1	7tmA_mAChR_M3	65..>269	CDD:320426	68/214 (32%)
		TM helix 1	69..95	CDD:320426	11/25 (44%)
		TM helix 2	102..129	CDD:320426	7/26 (27%)
		TM helix 3	140..170	CDD:320426	12/29 (41%)
		TM helix 4	182..205	CDD:320426	7/23 (30%)
		TM helix 5	227..256	CDD:320426	8/29 (28%)
		Basolateral sorting signal. /evidence=ECO:0000250	274..280		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	275..295		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..356		5/35 (14%)
		7tm_GPCRs	<483..563	CDD:475119	24/83 (29%)
		TM helix 6	489..511	CDD:410628	6/21 (29%)
		TM helix 7	522..547	CDD:410628	7/27 (26%)