DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TyrRII and Adrb1

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_031445.2 Gene:Adrb1 / 11554 MGIID:87937 Length:466 Species:Mus musculus


Alignment Length:554 Identity:143/554 - (25%)
Similarity:208/554 - (37%) Gaps:197/554 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 TSAAPGGDVMATGAGAGKLGVP--------SMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVI 96
            :||||..|..||.|....|..|        |..|..:|..|...:.:.:.|:::|: ||||.|||
Mouse    17 SSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLI-VVGNVLVI 80

  Fly    97 LAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGS 161
            :|:..|.||:|:||.|:|:||..|.::|..|:|....:.:.|.|.:|...|::|.|:|:|..:.|
Mouse    81 VAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTAS 145

  Fly   162 ILSLCAISLDRYLAVTQPLTY-SKKRRSKRLALLMILVVW-ITALSITCPPYLGWYEVGRHQAE- 223
            |.:||.|:||||||:|.|..| |...|::..||  :..|| |:||....|..:.|:.....:|. 
Mouse   146 IETLCVIALDRYLAITSPFRYQSLLTRARARAL--VCTVWAISALVSFLPILMHWWRAESDEARR 208

  Fly   224 -FVD---CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVD 284
             :.|   |.:..|:.|.:.|::.||::||.:|.:||:           |:.|:|           
Mouse   209 CYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYL-----------RVFREA----------- 251

  Fly   285 GDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGT 349
                                                           |..||  |...|....  
Mouse   252 -----------------------------------------------QKQVK--KIDSCERRF-- 265

  Fly   350 AGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASF 414
                                                       .|||....:|......|.... 
Mouse   266 -------------------------------------------LGGPARPPSPEPSPSPGPPRP- 286

  Fly   415 SDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNH 479
            :|:...|                                 |||                      
Mouse   287 ADSLANG---------------------------------RSS---------------------- 296

  Fly   480 HHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVN 544
             .|.|.|: ...|:.|..|||.|:||....||||||:..::..| .|..|.:.|...|.|:|:.|
Mouse   297 -KRRPSRL-VALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF-HRDLVPDRLFVFFNWLGYAN 358

  Fly   545 CAINPFIYAFYNPDFRTAFWRLTC---RPICKQK 575
            .|.||.||. .:||||.||.||.|   |..|:::
Mouse   359 SAFNPIIYC-RSPDFRKAFQRLLCCARRAACRRR 391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 71/198 (36%)
TM helix 1 78..101 CDD:410628 10/22 (45%)
TM helix 2 110..132 CDD:410628 9/21 (43%)
TM helix 3 148..170 CDD:410628 9/21 (43%)
TM helix 4 194..210 CDD:410628 5/16 (31%)
TM helix 5 233..256 CDD:410628 8/22 (36%)
7tm_GPCRs <491..563 CDD:475119 31/71 (44%)
TM helix 6 497..519 CDD:320098 12/21 (57%)
TM helix 7 531..556 CDD:320098 10/24 (42%)
Adrb1NP_031445.2 7tmA_Beta1_AR 59..376 CDD:320624 122/495 (25%)
TM helix 1 60..86 CDD:320624 10/26 (38%)
TM helix 2 93..120 CDD:320624 10/26 (38%)
TM helix 3 131..161 CDD:320624 16/29 (55%)
TM helix 4 175..193 CDD:320624 7/19 (37%)
TM helix 5 221..253 CDD:320624 13/100 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..302 12/139 (9%)
TM helix 6 306..336 CDD:320624 14/29 (48%)
TM helix 7 345..370 CDD:320624 10/25 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..466
PDZ-Binding. /evidence=ECO:0000250 463..466
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.