DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and Adra2c

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_031444.2 Gene:Adra2c / 11553 MGIID:87936 Length:458 Species:Mus musculus


Alignment Length:575 Identity:154/575 - (26%)
Similarity:236/575 - (41%) Gaps:146/575 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 SKLLSTALTVASGNS-NSSDGTLLLIQTSAAPGGDVMATGAGAGKLG---VPSMNSY----LVSM 70
            |..|:.||..|:... |.||            .|: ..:|.||...|   ||....|    :..:
Mouse     3 SPALAAALAAAAAEGPNGSD------------AGE-WGSGGGANASGTDWVPPPGQYSAGAVAGL 54

  Fly    71 AWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLY 135
            |     ||..||::.  |||||.||::||||:|.||...|.|:::||..|.||.|.|||.|:...
Mouse    55 A-----AVVGFLIVF--TVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANE 112

  Fly   136 ITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVW 200
            :...|.||.:.|.::::||:|.|:.||:.|||||||||.:|||.:.|:.||..:|:. ..|:.||
Mouse   113 LMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVK-ATIVAVW 176

  Fly   201 ITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSR 265
            :.:..|:.||.:.:|. ....|.:..|..|....|::.|.:||||.|..:|..||.:| |.:...
Mouse   177 LISAVISFPPLVSFYR-RPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARI-YRVAKL 239

  Fly   266 RQRIVRDAYSERTADYDVDGDNFISES-------EHYHCTPTKWLPNRKSRWRFNSLHDPPPSAA 323
            |.|.:    ||:......||.:..:|:       |:.||.|.:              .:..|..:
Mouse   240 RTRTL----SEKRGPAGPDGASPTTENGLGKAAGENGHCAPPR--------------TEVEPDES 286

  Fly   324 TNAAAKGHQSSVKCS--KCSKCSSATGTA-GAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIH 385
            :.|..:..:.:::..  :.......||:| |.|.|........|....|                
Mouse   287 SAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSP---------------- 335

  Fly   386 CSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQK 450
                     ||                       ||.:|..::.:....::             :
Mouse   336 ---------GP-----------------------GGRLSRASSRSVEFFLS-------------R 355

  Fly   451 QQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFF 515
            :::.|||                         :..|.....|:.:....|.:|||..:.||.|||
Mouse   356 RRRARSS-------------------------VCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFF 395

  Fly   516 VYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCR 569
            ..|.|.........|.:.:|. |.|||:.|.::||.||..:|.|||.:|..:..|
Mouse   396 FSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFR 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 79/191 (41%)
TM helix 1 78..101 CDD:410628 12/22 (55%)
TM helix 2 110..132 CDD:410628 11/21 (52%)
TM helix 3 148..170 CDD:410628 10/21 (48%)
TM helix 4 194..210 CDD:410628 4/15 (27%)
TM helix 5 233..256 CDD:410628 9/22 (41%)
7tm_GPCRs <491..563 CDD:475119 27/72 (38%)
TM helix 6 497..519 CDD:320098 9/21 (43%)
TM helix 7 531..556 CDD:320098 10/25 (40%)
Adra2cNP_031444.2 7tmA_alpha2C_AR 60..444 CDD:320446 133/492 (27%)
TM helix 2 86..112 CDD:320446 12/25 (48%)
TM helix 3 124..154 CDD:320446 16/29 (55%)
TM helix 4 166..189 CDD:320446 7/23 (30%)
TM helix 5 207..236 CDD:320446 12/29 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..343 23/159 (14%)
TM helix 6 371..401 CDD:320446 11/29 (38%)
TM helix 7 412..437 CDD:320446 10/24 (42%)

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