Protein Alignment TyrRII and Adra1d

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_038488.4
• Gene: Adra1d / 11550
• MGIID: 106673
• Length: 562
• Species: Mus musculus
• Alignment Length: 563
• Identity: 145/563 - (25%)
• Similarity: 212/563 - (37%)
• Gaps: 196/563 - (34%)

  Fly    18 STALTVASGNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFL 82
            |..:...||..|.|.    ..:..||..|:|..:.|..|          ||..|  :.:.|.|||
Mouse    49 SAVVGTGSGEDNQSS----TAEAGAAASGEVNGSAAVGG----------LVVSA--QGVGVGVFL 97

  Fly    83 -VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWIL 146
             ..||..|.||.||||:|...|.|:||||.|::|||:.|.|:...|:|.|..:.:.|.|.||...
Mouse    98 AAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTF 162

  Fly   147 CDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPY 211
            ||:|.::|:|.|:.||||||.||:|||:.|...|.|......::.|.::.| :|..||.::..|.
Mouse   163 CDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILAL-LWAVALVVSVGPL 226

  Fly   212 LGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSE 276
            |||.|.......|  |...:..||.:||::.||::|:.|::.:|.:: ||:
Mouse   227 LGWKEPVPPDERF--CGITEEVGYAIFSSVCSFYLPMAVIVVMYCRV-YVV-------------- 274

  Fly   277 RTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCS 341
                                                                             
Mouse   275 ----------------------------------------------------------------- 274

  Fly   342 KCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHC--SAISCKYGGPCMHSTPSG 404
             ..|.|.:..||           .|.:|.     :.|.:...|||  :|.|.| |.|
Mouse   275 -ARSTTRSLEAG-----------IKREPG-----KASEVVLRIHCRGAATSAK-GNP-------- 313

  Fly   405 MHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHG 469
                ||::|                                    |....|||
Mouse   314 ----GTQSS------------------------------------KGHTLRSS------------ 326

  Fly   470 SHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLM 534
                         :.:|:....|:.|.||||.||:|..:.||.|||....|....|:....|.:.
Mouse   327 -------------LSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVF 378

  Fly   535 FGFTWIGWVNCAINPFIYAFYNPDFRTAFWR-LTCRPICKQKR 576
            ....|:|:.|..:||.||...:.:|:.||.| |.|:  |:::|
Mouse   379 KVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ--CRRRR 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	76/192 (40%)
		TM helix 1	78..101	CDD:410628	14/23 (61%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	12/21 (57%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	8/22 (36%)
		7tm_GPCRs	<491..563	CDD:475119	25/71 (35%)
		TM helix 6	497..519	CDD:320098	12/21 (57%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
Adra1d	NP_038488.4	7tm_GPCRs	91..407	CDD:475119	124/489 (25%)
		TM helix 1	93..117	CDD:410628	14/23 (61%)
		TM helix 2	126..148	CDD:410628	9/21 (43%)
		TM helix 3	164..186	CDD:410628	12/21 (57%)
		TM helix 4	209..225	CDD:410628	4/16 (25%)
		TM helix 5	246..269	CDD:410628	8/22 (36%)
		TM helix 6	341..363	CDD:410628	12/21 (57%)
		TM helix 7	375..400	CDD:410628	8/24 (33%)