DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and Adra1a

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_038489.2 Gene:Adra1a / 11549 MGIID:104773 Length:466 Species:Mus musculus


Alignment Length:539 Identity:134/539 - (24%)
Similarity:205/539 - (38%) Gaps:214/539 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 KSLAVAVFL-VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYIT 137
            |::.:.|.| .:|:..|:||.||||:|...|.|.:||:.:::|||:.|.|:.:.|:|.|.:..|.
Mouse    25 KAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL 89

  Fly   138 GTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYS---KKRRSKRLALLMILVV 199
            |.|.||.:.|:||.::|:|.|:.||:.||.||:|||:.|:.||.|.   .:||..|    .:|.|
Mouse    90 GYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVR----ALLCV 150

  Fly   200 WITALSITCPPYLGWYEVGRHQA--EFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVL 262
            |..:|.|:..|..||    |.||  :...|:.|:..|||:|||:|||::|||::|.:|.:: ||:
Mouse   151 WALSLVISIGPLFGW----RQQAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRV-YVV 210

  Fly   263 TSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAA 327
            ..|..|                                                           
Mouse   211 AKRESR----------------------------------------------------------- 216

  Fly   328 AKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCK 392
              |.:|.:|..|                                                     
Mouse   217 --GLKSGLKTDK----------------------------------------------------- 226

  Fly   393 YGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSS 457
                                  ||:                                    ::.:
Mouse   227 ----------------------SDS------------------------------------EQVT 233

  Fly   458 FDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIP 522
            ...|..:....|| |..|..|..| ..:|:....|:.|.||||.||:|..:.||||||:...:..
Mouse   234 LRIHRKNVPAEGS-GVSSAKNKTH-FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGS 296

  Fly   523 FLPR---PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKR-------- 576
            |.|.   |..:..::|   |:|::|..|||.||...:.:|:.||..: .|..|.::|        
Mouse   297 FFPNFKPPETVFKIVF---WLGYLNSCINPIIYPCSSQEFKKAFQNV-LRIQCLRRRQSSKHALG 357

  Fly   577 ----PPN------HLAMFR 585
                ||:      |..|.|
Mouse   358 YTLHPPSQAVEGQHRGMVR 376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 81/197 (41%)
TM helix 1 78..101 CDD:410628 11/23 (48%)
TM helix 2 110..132 CDD:410628 7/21 (33%)
TM helix 3 148..170 CDD:410628 10/21 (48%)
TM helix 4 194..210 CDD:410628 5/15 (33%)
TM helix 5 233..256 CDD:410628 13/22 (59%)
7tm_GPCRs <491..563 CDD:475119 28/74 (38%)
TM helix 6 497..519 CDD:320098 13/21 (62%)
TM helix 7 531..556 CDD:320098 9/24 (38%)
Adra1aNP_038489.2 7tmA_alpha1A_AR 27..337 CDD:320448 123/495 (25%)
TM helix 1 28..54 CDD:320448 11/25 (44%)
TM helix 2 61..87 CDD:320448 9/25 (36%)
TM helix 3 99..129 CDD:320448 15/29 (52%)
TM helix 4 141..164 CDD:320448 9/26 (35%)
TM helix 5 181..210 CDD:320448 15/29 (52%)
TM helix 6 265..295 CDD:320448 15/29 (52%)
TM helix 7 305..330 CDD:320448 9/27 (33%)
Nuclear localization signal. /evidence=ECO:0000250 334..349 4/15 (27%)

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