DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and CHRM5

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_036257.1 Gene:CHRM5 / 1133 HGNCID:1954 Length:532 Species:Homo sapiens


Alignment Length:564 Identity:142/564 - (25%)
Similarity:236/564 - (41%) Gaps:134/564 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 WPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYI 136
            |......||..|:.|:|:|||.||:::.....:|:||.|.::::||..|.::|...|.......:
Human    28 WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYIL 92

  Fly   137 TGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWI 201
            .|.|..|.:.||:|::||.:..:.|:::|..||.|||.::|:||||..||..|| |.:||.:.|:
Human    93 MGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKR-AGIMIGLAWL 156

  Fly   202 TALSITCPPYLGW-YEVGRHQAEFVDCRYN-QNKGYVVF-SAMGSFFIPLTVMLYVYVKIGYVLT 263
            .:..:..|..|.| |.||:......:|:.. .::..:.| :|:.:|:||::||..:|.       
Human   157 ISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYC------- 214

  Fly   264 SRRQRIVRDAYSERTADY-DVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAA 327
                ||.|:. .:||.|. |:.|.:.::::|       |..|..::.:| :.|..|.|:.|....
Human   215 ----RIYRET-EKRTKDLADLQGSDSVTKAE-------KRKPAHRALFR-SCLRCPRPTLAQRER 266

  Fly   328 AKGHQSSVK--CSKCSKCSSATGTAGAGAGAGVVDKTLTF-----KHQPTFYELVEVSRLSSLIH 385
            .:...||.:  .|...|.|.|||.:...|.|..:....::     :.:|....:::|...|    
Human   267 NQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS---- 327

  Fly   386 CSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQK 450
                             .|....|.|.|..:|                   .||..|.|.|    
Human   328 -----------------QGKESPGEEFSAEET-------------------EETFVKAETE---- 352

  Fly   451 QQQQRSSFDHHH----PHAHHH---------------GSHGQQSHHNHHHRM-----PMRVS--- 488
                :|.:|..:    |.|.|.               .:.|.|..:|..|::     |..|:   
Human   353 ----KSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEP 413

  Fly   489 ------------TTKR-------DSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPR--PAVLED 532
                        .|||       :.|.|:||:.::...|..|.|:.:..|:..|..:  |..|..
Human   414 STKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWH 478

  Fly   533 LMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKR 576
            |.:   |:.:||..:||..||..|..||..|..|.   :|:.|:
Human   479 LGY---WLCYVNSTVNPICYALCNRTFRKTFKMLL---LCRWKK 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 63/194 (32%)
TM helix 1 78..101 CDD:410628 10/22 (45%)
TM helix 2 110..132 CDD:410628 6/21 (29%)
TM helix 3 148..170 CDD:410628 7/21 (33%)
TM helix 4 194..210 CDD:410628 3/15 (20%)
TM helix 5 233..256 CDD:410628 7/23 (30%)
7tm_GPCRs <491..563 CDD:475119 24/80 (30%)
TM helix 6 497..519 CDD:320098 6/21 (29%)
TM helix 7 531..556 CDD:320098 8/24 (33%)
CHRM5NP_036257.1 7tmA_mAChR_M5 31..>225 CDD:320427 66/206 (32%)
TM helix 1 32..58 CDD:320427 10/25 (40%)
TM helix 2 65..91 CDD:320427 6/25 (24%)
TM helix 3 103..133 CDD:320427 12/29 (41%)
TM helix 4 145..168 CDD:320427 7/23 (30%)
TM helix 5 190..219 CDD:320427 10/39 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..294 9/31 (29%)
7tm_GPCRs <435..514 CDD:475119 25/84 (30%)
TM helix 6 441..463 CDD:410628 6/21 (29%)
TM helix 7 474..499 CDD:410628 9/27 (33%)

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