DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and CHRM4

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000732.2 Gene:CHRM4 / 1132 HGNCID:1953 Length:479 Species:Homo sapiens


Alignment Length:543 Identity:125/543 - (23%)
Similarity:211/543 - (38%) Gaps:149/543 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 VFLVII-----LVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGT 139
            ||:..:     |||||||.||:|::...|:|:||.|.|:.:||..|.::|...|....|..|.|.
Human    33 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGY 97

  Fly   140 WRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITAL 204
            |..|.::||:|::||.::.:.|:::|..||.|||..||:|||| ..||:.::|.|||...|:.:.
Human    98 WPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTY-PARRTTKMAGLMIAAAWVLSF 161

  Fly   205 SITCPPYLGW-YEVGRHQAEFVDC--RYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRR 266
            .:..|..|.| :.||:.......|  ::..|......:|:.:|::|:.:|..:|:.|.....||.
Human   162 VLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRV 226

  Fly   267 QRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAA-------- 323
            .:...:...|:.|                     |.|...||.....|:..|||..|        
Human   227 HKHRPEGPKEKKA---------------------KTLAFLKSPLMKQSVKKPPPGEAAREELRNG 270

  Fly   324 ----------------------TNAAAKGHQS-SVKCSKCSKCSSATGTAGAGAGAGVVDKTLTF 365
                                  :|.::.|..: :.|....::.|:...|..|.....:..:.|. 
Human   271 KLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALN- 334

  Fly   366 KHQPTFYELVEVSRLSSLIHCSAISCKYGGPC------MHSTPSGMHYVGTEASFSDTCLGGNVS 424
                      ..||.|.:   ..::.:.|..|      :.:||:||.            ...||:
Human   335 ----------PASRWSKI---QIVTKQTGNECVTAIEIVPATPAGMR------------PAANVA 374

  Fly   425 NNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVST 489
            ....:...|.|            ::|:|.                                    
Human   375 RKFASIARNQV------------RKKRQM------------------------------------ 391

  Fly   490 TKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMF--GFTWIGWVNCAINPFIY 552
            ..|:.|..:|:..::...|..|.|:.|..|:..|.  .:.:.|.::  |: |:.:||..|||..|
Human   392 AARERKVTRTIFAILLAFILTWTPYNVMVLVNTFC--QSCIPDTVWSIGY-WLCYVNSTINPACY 453

  Fly   553 AFYNPDFRTAFWRLTCRPICKQK 575
            |..|..|:..|..|.   :|:.:
Human   454 ALCNATFKKTFRHLL---LCQYR 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 68/197 (35%)
TM helix 1 78..101 CDD:410628 12/25 (48%)
TM helix 2 110..132 CDD:410628 7/21 (33%)
TM helix 3 148..170 CDD:410628 7/21 (33%)
TM helix 4 194..210 CDD:410628 4/15 (27%)
TM helix 5 233..256 CDD:410628 4/22 (18%)
7tm_GPCRs <491..563 CDD:475119 21/73 (29%)
TM helix 6 497..519 CDD:320098 5/21 (24%)
TM helix 7 531..556 CDD:320098 10/26 (38%)
CHRM4NP_000732.2 7tmA_mAChR_M4 33..464 CDD:341344 122/529 (23%)
TM helix 1 34..60 CDD:341344 11/25 (44%)
TM helix 2 67..93 CDD:341344 8/25 (32%)
TM helix 3 105..135 CDD:341344 12/29 (41%)
TM helix 4 147..170 CDD:341344 6/22 (27%)
TM helix 5 192..221 CDD:341344 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 271..333 6/61 (10%)
TM helix 6 393..423 CDD:341344 8/29 (28%)
TM helix 7 432..457 CDD:341344 10/25 (40%)

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