Protein Alignment TyrRII and CHRM3

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_000731.1
• Gene: CHRM3 / 1131
• HGNCID: 1952
• Length: 590
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 151/631 - (23%)
• Similarity: 251/631 - (39%)
• Gaps: 150/631 - (23%)

  Fly     8 DAMLPYSKLL---STALTVASGNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVS 69
            ||.||...:.   |..::.|:||.:|.|||     |....||..:
Human    26 DAGLPPGTVTHFGSYNVSRAAGNFSSPDGT-----TDDPLGGHTV-------------------- 65

  Fly    70 MAWPKSLAVAVFL--VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSV 132
              |  .:....||  ::.|||::||.|||::....::|:||.|.|:::||..|.::|...|....
Human    66 --W--QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126

  Fly   133 VLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMIL 197
            ...|...|..|.:.||:|:::|.:..:.|:::|..||.|||.::|:||||..||.:|| |.:||.
Human   127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKR-AGVMIG 190

  Fly   198 VVWITALSITCPPYLGW-YEVGRHQAEFVDCRYNQNKGYVVF---------SAMGSFFIPLTVML 252
            :.|:.:..:..|..|.| |.||:......:|       ::.|         :|:.:|::|:|:|.
Human   191 LAWVISFVLWAPAILFWQYFVGKRTVPPGEC-------FIQFLSEPTITFGTAIAAFYMPVTIMT 248

  Fly   253 YVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFI---------SESE--------------- 293
            .:|.:| |..|.:|.:.:....:..|   :.:.:||:         |..|
Human   249 ILYWRI-YKETEKRTKELAGLQASGT---EAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYG 309

  Fly   294 --HYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGA 356
              |:..|...|.|:.:   :.:..|....|...|.||...::|        .||.....|:...|
Human   310 RCHFWFTTKSWKPSSE---QMDQDHSSSDSWNNNDAAASLENS--------ASSDEEDIGSETRA 363

  Fly   357 GVVDKTLTFKHQPTFYE------------------LVEVSRLSSLIHCSAISCKYGGPCMHSTPS 403
             :....|......|...                  :|::.|.:..:.... |...||    |.|.
Human   364 -IYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQK-SVDDGG----SFPK 422

  Fly   404 GMHYVGTE-ASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHH 467
            ....:..: .|..||....:| |::...:|.|:.|...|  ...||:...:.||.....
Human   423 SFSKLPIQLESAVDTAKTSDV-NSSVGKSTATLPLSFKE--ATLAKRFALKTRSQITKR------ 478

  Fly   468 HGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPR--PAVL 530
                             .|:|..| :.|.|:||:.::...|..|.|:.:..|:..|...  |...
Human   479 -----------------KRMSLVK-EKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTF 525

  Fly   531 EDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKR 576
            .:|.:   |:.::|..:||..||..|..|||.|..|......|:||
Human   526 WNLGY---WLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKR 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	65/203 (32%)
		TM helix 1	78..101	CDD:410628	10/24 (42%)
		TM helix 2	110..132	CDD:410628	7/21 (33%)
		TM helix 3	148..170	CDD:410628	6/21 (29%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	6/31 (19%)
		7tm_GPCRs	<491..563	CDD:475119	22/73 (30%)
		TM helix 6	497..519	CDD:320098	6/21 (29%)
		TM helix 7	531..556	CDD:320098	7/24 (29%)
CHRM3	NP_000731.1	7tmA_mAChR_M3	66..>270	CDD:320426	66/214 (31%)
		TM helix 1	70..96	CDD:320426	10/25 (40%)
		TM helix 2	103..130	CDD:320426	7/26 (27%)
		TM helix 3	141..171	CDD:320426	11/29 (38%)
		TM helix 4	183..206	CDD:320426	7/23 (30%)
		TM helix 5	228..257	CDD:320426	8/29 (28%)
		Basolateral sorting signal	275..281		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..357		8/44 (18%)
		7tm_GPCRs	<484..564	CDD:475119	24/83 (29%)
		TM helix 6	490..512	CDD:320426	6/21 (29%)
		TM helix 7	523..548	CDD:320426	7/27 (26%)