DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and HRH3

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:XP_005260323.1 Gene:HRH3 / 11255 HGNCID:5184 Length:453 Species:Homo sapiens


Alignment Length:554 Identity:141/554 - (25%)
Similarity:222/554 - (40%) Gaps:146/554 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 AAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLR 106
            |.|.|.:.|:||.||:..... .:...|.||...|| |:..::|:.||:||.||:||.:....||
Human     4 APPDGPLNASGALAGEAAAAG-GARGFSAAWTAVLA-ALMALLIVATVLGNALVMLAFVADSSLR 66

  Fly   107 TVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLD 171
            |..|.|::||||:|:|||...:|..|...:||.|.||..||.:|:.:|.|||:.|..::..||.|
Human    67 TQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYD 131

  Fly   172 RYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEV--------GRHQAEFVDCR 228
            |:|:||:.::|..::...|.|:..:|:||:.|..:..|..|.|..:        |...|||.   
Human   132 RFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFF--- 193

  Fly   229 YNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESE 293
            ||..  :::.::...||.|...:.:..:.| |:...||.|:..|...|.....            
Human   194 YNWY--FLITASTLEFFTPFLSVTFFNLSI-YLNIQRRTRLRLDGAREAAGPE------------ 243

  Fly   294 HYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGV 358
                .|.:..|:           .|||........|||..::...:     ...|.|..||.|| 
Human   244 ----PPPEAQPS-----------PPPPPGCWGCWQKGHGEAMPLHR-----YGVGEAAVGAEAG- 287

  Fly   359 VDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNV 423
                                                                ||:......||:|
Human   288 ----------------------------------------------------EATLGGGGGGGSV 300

  Fly   424 SNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVS 488
            ::.|:::.:::...|                       .|.:...||....|..:...||.| ||
Human   301 ASPTSSSGSSSRGTE-----------------------RPRSLKRGSKPSASSASLEKRMKM-VS 341

  Fly   489 TT-------KRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPA----VLEDLMFGFT-WIG 541
            .:       .||.|.||:|.:::.....||.|:.:..::     |.|    .:.|..:..: |:.
Human   342 QSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMII-----RAACHGHCVPDYWYETSFWLL 401

  Fly   542 WVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQK 575
            |.|.|:||.:|...:..||.||.:|    :|.||
Human   402 WANSAVNPVLYPLCHHSFRRAFTKL----LCPQK 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 69/199 (35%)
TM helix 1 78..101 CDD:410628 10/22 (45%)
TM helix 2 110..132 CDD:410628 11/21 (52%)
TM helix 3 148..170 CDD:410628 7/21 (33%)
TM helix 4 194..210 CDD:410628 4/15 (27%)
TM helix 5 233..256 CDD:410628 3/22 (14%)
7tm_GPCRs <491..563 CDD:475119 21/76 (28%)
TM helix 6 497..519 CDD:320098 6/21 (29%)
TM helix 7 531..556 CDD:320098 8/25 (32%)
HRH3XP_005260323.1 7tmA_Histamine_H3R 48..423 CDD:320423 120/494 (24%)
TM helix 2 69..96 CDD:320423 12/26 (46%)
TM helix 3 107..137 CDD:320423 12/29 (41%)
TM helix 4 152..170 CDD:320423 5/17 (29%)
TM helix 5 195..225 CDD:320423 6/32 (19%)
TM helix 6 351..381 CDD:320423 9/34 (26%)
TM helix 7 391..416 CDD:320423 8/24 (33%)

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