Protein Alignment TyrRII and LOC11175717

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_061507703.1
• Gene: LOC11175717 / 11175717
• VectorBaseID: AGAMI1_012729
• Length: 809
• Species: Anopheles gambiae
• Alignment Length: 703
• Identity: 271/703 - (38%)
• Similarity: 360/703 - (51%)
• Gaps: 189/703 - (26%)

  Fly    18 STALTVASGNSNSSDGTLLLIQTSAAPGGDVMATGAGAG----------------KLGVPS-MNS 65
            :|..||:.||:.....|:...:.....|..::.:|..|.                :|.:|| |:.
Mosquito   141 ATITTVSIGNTTVQPATVFGPRPGVTDGSVLIGSGTSAATTLVVDLVGTVDPTARQLELPSAMDE 205

  Fly    66 YLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPP 130
            :.:...|...:.|.:|.::|:|||:|||||||:|:||||||||||||||:||:.|||||..||||
Mosquito   206 HFLIANWQDCVVVILFCLLIVVTVIGNTLVILSVITTRRLRTVTNCFVMSLAVADWLVGIFVMPP 270

  Fly   131 SVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLM 195
            :|.:::.|:|:.||||||||||||:|||:.|||||||||:||||||||||.||::||||||||||
Mosquito   271 AVAVHLMGSWQLGWILCDIWISLDVLLCTASILSLCAISIDRYLAVTQPLNYSRRRRSKRLALLM 335

  Fly   196 ILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGY 260
            |||||:.||:|||||.|||||.||.:.:  .||||||:||||||||||||||:|||:||||:|..
Mosquito   336 ILVVWVLALAITCPPILGWYEPGRRELD--QCRYNQNEGYVVFSAMGSFFIPMTVMVYVYVRISC 398

  Fly   261 VLTSRRQRIVR---DAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSA 322
            |:.||..::..   ...|.|..:.:.||                          :.|..||.|
Mosquito   399 VVASRHDKMTEIEVHKKSHRVREPEEDG--------------------------YQSEQDPIP-- 435

  Fly   323 ATNAAAKGHQSSVKCSKCSKCSSATGTAGA--------GAGAGVVDKTLTFK--HQPTFYELVEV 377
               .:.|..:||      |:.|:||.|..|        |.|||...|....:  |:...|||:::
Mosquito   436 ---LSPKRKRSS------SQLSTATTTYVAQLGPMLDEGVGAGQPPKPAGKRNNHKHGHYELMDL 491

  Fly   378 -----SRLSSLIHCSAISCKYGGPCMH-STPS----GMHY-------------VGTEASFSDTCL 419
                 |..|.....:|.....|||... ||.|    |.|:             ...:|...|..:
Mosquito   492 NTTGGSTQSQTTILAAAGNGTGGPTGDTSTASAAAEGHHHHQEQLRQRTYDDGTSLDAIVDDPAV 556

  Fly   420 ------GGNVSNNTTT--TTTNTVALETN-EKLEAEAK--------------QKQQQQRSSFD-- 459
                  .|:..:||:|  ||...|:...| .||.:.|:              :.|....:||.
Mosquito   557 VLAGPGSGSTESNTSTAATTAAPVSASVNYNKLPSTAELWSSGNSVFNQQSHKPQSHSMASFAGA 621

  Fly   460 -------------HHHPHAHHHGSHGQQSHHNHHHR----------------------------- 482
                         |||.|.|||       ||:|||.
Mosquito   622 AGAGSPPNHSQHFHHHHHHHHH-------HHHHHHEGRPTAALAAATGGLRRNNTVNTSITTSTC 679

  Fly   483 ---------------------MPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPR 526
                                 :..|:|:.||::||.:||:||:||.||||||||::|::.||||:
Mosquito   680 SSVQLVGGRTGGNNIRIHQKSLSSRISSMKRENKTTRTLSIVVGGFIACWLPFFIHYIITPFLPK 744

  Fly   527 PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICK--QKRP 577
            ...:..|...|||:||:|.||||||||||:.|||.||||||.|...:  :|.|
Mosquito   745 DWTVPKLSEFFTWLGWINSAINPFIYAFYSVDFRAAFWRLTLRRFFRNSEKAP 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	138/191 (72%)
		TM helix 1	78..101	CDD:410628	14/22 (64%)
		TM helix 2	110..132	CDD:410628	16/21 (76%)
		TM helix 3	148..170	CDD:410628	18/21 (86%)
		TM helix 4	194..210	CDD:410628	12/15 (80%)
		TM helix 5	233..256	CDD:410628	19/22 (86%)
		7tm_GPCRs	<491..563	CDD:475119	43/71 (61%)
		TM helix 6	497..519	CDD:320098	14/21 (67%)
		TM helix 7	531..556	CDD:320098	16/24 (67%)
LOC11175717	XP_061507703.1	None