DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and htr2c

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:XP_017951833.1 Gene:htr2c / 100496012 XenbaseID:XB-GENE-967634 Length:475 Species:Xenopus tropicalis


Alignment Length:567 Identity:131/567 - (23%)
Similarity:208/567 - (36%) Gaps:226/567 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 MATGAGAGKL----GVPSMNSYLVS-----MAW-------------------------------- 72
            |:|..|.|||    .|....|..:|     |||                                
 Frog     1 MSTFGGTGKLVSLTTVSITRSVDISFHNGLMAWHVNNNVTLNQSMPTSAPANASEEEKLSHESLA 65

  Fly    73 PKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYIT 137
            .|:.:..:.|:||::|:.||.|||:||...::|:..||.|:|:||:.|.|||..|||.|:|   |
 Frog    66 DKNWSALLTLIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLV---T 127

  Fly   138 GTWRFGW----ILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILV 198
            ..:.:.|    .||.||||||:|..:.||:.|||||||||:|:..|:.:| :..|:..|::.|..
 Frog   128 ILYDYAWPLPRKLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHS-RFNSRTKAMMKIAA 191

  Fly   199 VWITALSITCP-PYLGWYEVGRHQAEFVD--CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGY 260
            ||..::.|:.| |.:|..:..|   .||:  |..| ::.:|:..:..:|||||.:|::.|.....
 Frog   192 VWTISIGISMPVPVIGLQDDSR---VFVNSSCVLN-DENFVLLGSFVAFFIPLIIMVFTYCLTIQ 252

  Fly   261 VLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATN 325
            ||  ::|..|                 |:.|.                                 
 Frog   253 VL--QKQATV-----------------FMYEE--------------------------------- 265

  Fly   326 AAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAIS 390
             ..|..:|||.|.|                                                   
 Frog   266 -VPKQRRSSVNCLK--------------------------------------------------- 278

  Fly   391 CKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQR 455
                                            ..||     |..:::..|.:..:.......::.
 Frog   279 --------------------------------KENN-----TENISMIQNHEAASHLNSPINKEG 306

  Fly   456 SSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLL 520
            :.|        ..|:  .||.:|              :.:.:|.|.||....:..|.|||:..::
 Frog   307 ALF--------RKGT--MQSINN--------------ERRASKVLGIVFFLFLIMWCPFFITNIM 347

  Fly   521 IPFLPRPA----VLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF 563
             ..|.:.|    ::.:|:..|.|:|:|:..|||.:|..:|..:|.||
 Frog   348 -SVLCKEACDNELMVELLNVFVWVGYVSSGINPLVYTLFNRTYRRAF 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 77/198 (39%)
TM helix 1 78..101 CDD:410628 11/22 (50%)
TM helix 2 110..132 CDD:410628 12/21 (57%)
TM helix 3 148..170 CDD:410628 13/21 (62%)
TM helix 4 194..210 CDD:410628 5/16 (31%)
TM helix 5 233..256 CDD:410628 7/22 (32%)
7tm_GPCRs <491..563 CDD:475119 21/75 (28%)
TM helix 6 497..519 CDD:320098 8/21 (38%)
TM helix 7 531..556 CDD:320098 9/24 (38%)
htr2cXP_017951833.1 7tmA_5-HT2C 68..399 CDD:341346 118/500 (24%)
TM helix 1 69..95 CDD:341346 11/25 (44%)
TM helix 2 102..128 CDD:341346 15/28 (54%)
TM helix 3 141..171 CDD:341346 20/29 (69%)
TM helix 4 183..206 CDD:341346 7/22 (32%)
TM helix 5 224..253 CDD:341346 8/28 (29%)
TM helix 6 318..348 CDD:341346 9/44 (20%)
TM helix 7 361..386 CDD:341346 9/24 (38%)

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