Protein Alignment TyrRII and adra1d

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_002935531.2
• Gene: adra1d / 100495969
• XenbaseID: XB-GENE-6050827
• Length: 500
• Species: Xenopus tropicalis
• Alignment Length: 508
• Identity: 131/508 - (25%)
• Similarity: 202/508 - (39%)
• Gaps: 182/508 - (35%)

  Fly    75 SLAVAVFL-VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITG 138
            :|:|.:.| |.||..:|||.:|||:|...|:|:||||.|::||||.|.|:.|.|:|.|..|.:.|
 Frog    42 ALSVGIVLAVFILFAIVGNIMVILSVACNRQLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLG 106

  Fly   139 TWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITA 203
            .|.||.:.||||.::|:|.|:.||:|||.||:|||:.|...|.|......|: |:::::::|:::
 Frog   107 FWAFGRVFCDIWAAVDVLCCTASIMSLCVISIDRYVGVKYSLKYPTIMTEKK-AVVILILLWLSS 170

  Fly   204 LSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQR 268
            :.|:..|.|||.|  ....:...|...:..||.:||::.||::||.|:|.:|.:: |::..|
 Frog   171 MVISIGPLLGWKE--PPPPDDSKCSITEEPGYALFSSLFSFYLPLLVILVMYFRV-YIVARR--- 229

  Fly   269 IVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQS 333
                                                                      ..|..::
 Frog   230 ----------------------------------------------------------TTKSLEA 236

  Fly   334 SVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCM 398
            .||                             |.:....|:|      ..|||.::
 Frog   237 GVK-----------------------------KERNKSMEVV------LRIHCRSV--------- 257

  Fly   399 HSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHP 463
                       .|.|.|.|
 Frog   258 -----------LEESSSST---------------------------------------------- 265

  Fly   464 HAHHHGSHGQQSHHNHHHRMPMRVSTTK--RDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPR 526
                      ::|..|..|..:.|...|  |:.|.||||.||:|..|.||||||:...|..|.|.
 Frog   266 ----------RNHKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFILCWLPFFLILPLGSFFPA 320

  Fly   527 PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWR-LTCRPICKQKRPP 578
            ....:.:.....|:|:.|..:||.||...:.:|:.||.| |.|:  |:::|.|
 Frog   321 LKPTDSVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAFIRILKCQ--CRRRRRP 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	77/192 (40%)
		TM helix 1	78..101	CDD:410628	12/23 (52%)
		TM helix 2	110..132	CDD:410628	11/21 (52%)
		TM helix 3	148..170	CDD:410628	12/21 (57%)
		TM helix 4	194..210	CDD:410628	2/15 (13%)
		TM helix 5	233..256	CDD:410628	10/22 (45%)
		7tm_GPCRs	<491..563	CDD:475119	28/73 (38%)
		TM helix 6	497..519	CDD:320098	14/21 (67%)
		TM helix 7	531..556	CDD:320098	7/24 (29%)
adra1d	XP_002935531.2	7tmA_alpha1D_AR	43..357	CDD:320450	123/489 (25%)
		TM helix 1	44..70	CDD:320450	12/25 (48%)
		TM helix 2	77..103	CDD:320450	13/25 (52%)
		TM helix 3	115..145	CDD:320450	17/29 (59%)
		TM helix 4	157..180	CDD:320450	5/23 (22%)
		TM helix 5	197..226	CDD:320450	12/29 (41%)
		TM helix 6	285..315	CDD:320450	16/29 (55%)
		TM helix 7	325..350	CDD:320450	7/24 (29%)