Protein Alignment TyrRII and htr4

DIOPT Version :9

• Sequence 1: NP_001262682.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_002939852.1
• Gene: htr4 / 100493952
• XenbaseID: XB-GENE-993770
• Length: 386
• Species: Xenopus tropicalis
• Alignment Length: 536
• Identity: 125/536 - (23%)
• Similarity: 187/536 - (34%)
• Gaps: 214/536 - (39%)

  Fly    55 AGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTV-TNCFVMNLAI 118
            |..:.|.|...|.|:   .:.:.::....:||:|::||.||::||...|:||.: ||.|:::||.
 Frog     2 AHNINVTSNEGYGVA---ARIVLISFISAVILMTILGNLLVMVAVCRDRQLRKIKTNYFIVSLAF 63

  Fly   119 TDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAV-TQPLTY 182
            .|.||...|||...:..:...|.:|.:.|.:..|||:||.:.|||.||.||||||.|: .|||.|
 Frog    64 ADLLVSVLVMPFGAIELVQEKWIYGEMFCLVRTSLDVLLTTASILHLCCISLDRYYAICCQPLVY 128

  Fly   183 SKKRRSKRLALLMILVVWITALSITCPPYL-GWYEVG----------RHQAEFVDCRYNQNKGYV 236
            ..|....|:. ||:...||....|:..|.: ||..:|          ...:...:|.:..||.|.
 Frog   129 RNKMTPLRIT-LMLSGCWIIPTFISFLPIMQGWNSIGILDLIETRKYNKSSNSTNCIFMVNKPYA 192

  Fly   237 VFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTK 301
            :..::.:|:||..:|:..|.:|                             :|:..||
 Frog   193 ITCSVVAFYIPFFLMVLAYYRI-----------------------------YITAREH------- 221

  Fly   302 WLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFK 366
                                                               ....||:.:.
 Frog   222 ---------------------------------------------------ARQIGVLQRA---- 231

  Fly   367 HQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTT 431
                                       |.|.
 Frog   232 ---------------------------GAPA---------------------------------- 235

  Fly   432 TNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKT 496
                                       ||.|.|...|.:          |||       |.::|.
 Frog   236 ---------------------------DHRHQHPDQHTT----------HRM-------KTETKA 256

  Fly   497 AKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRT 561
            ||||.|:||....||.|||:..::.||: ..:|..:|...|.|:|::|..:|||:|||.|..||.
 Frog   257 AKTLCIIMGCFCLCWAPFFITNVVDPFI-NYSVPVELWTAFLWLGYINSGLNPFLYAFLNKSFRR 320

  Fly   562 AFWRLTCRPICKQKRP 577
            ||..:.|....|.:||
 Frog   321 AFLIILCCGDEKYRRP 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	55/131 (42%)
		7tm_1	91..>277	CDD:278431	65/198 (33%)
htr4	XP_002939852.1	7tmA_5-HT4	19..322	CDD:320184	114/500 (23%)
		TM helix 1	20..46	CDD:320184	9/25 (36%)
		TM helix 2	54..80	CDD:320184	11/25 (44%)
		TM helix 3	92..122	CDD:320184	18/29 (62%)
		TM helix 4	135..158	CDD:320184	7/23 (30%)
		TM helix 5	188..217	CDD:320184	9/57 (16%)
		TM helix 6	251..281	CDD:320184	14/29 (48%)
		TM helix 7	290..315	CDD:320184	11/24 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000