Protein Alignment TyrRII and taar3

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_004914927.3
• Gene: taar3 / 100488107
• XenbaseID: XB-GENE-1011223
• Length: 335
• Species: Xenopus tropicalis
• Alignment Length: 522
• Identity: 111/522 - (21%)
• Similarity: 175/522 - (33%)
• Gaps: 242/522 - (46%)

  Fly    65 SYLVSMAWPKSLAVAVFLVI--ILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCV 127
            |.|.::..|.|.:|.:.:::  |::|.:||.:||::|...::|.:.||..:::||:||:|:|..:
 Frog    11 SCLGTIRSPASYSVMIIVMLGAIILTTIGNLMVIISVSHFKQLHSPTNFLILSLAVTDFLLGLVI 75

  Fly   128 MPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLA 192
            ||.|:|..:|..|.||.:.|.:...:|:.|.:.||..|..||:|||.||.|||.| .|..:..:.
 Frog    76 MPYSMVRSLTSCWYFGDLFCKLHGCIDMALSTSSIFHLFFISVDRYYAVCQPLHY-YKCITNNVI 139

  Fly   193 LLMILVVWITALSITCPPYLGWYEVG------------RHQAEFV---DCRYNQNKGYVVFSAMG 242
            .:.:.:.|    |::|     .|..|            .:.|.|.   .|....||.:...||:.
 Frog   140 QVFLFISW----SVSC-----LYSFGLVFSNIHTEGIQHYIASFTCTGSCSLAFNKIWGAISALI 195

  Fly   243 SFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRK 307
            |||||.|:|:.:|:.|
 Frog   196 SFFIPGTLMIGIYIHI------------------------------------------------- 211

  Fly   308 SRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFY 372
                                                                             
 Frog   212 ----------------------------------------------------------------- 211

  Fly   373 ELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVAL 437
                                                     ||       |:|.
 Frog   212 -----------------------------------------FS-------VANK----------- 217

  Fly   438 ETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSH-HNHHHRMPMRVS-----TTKRDSKT 496
                                               |..| ||||:..|.|.|     :.:.:||.
 Frog   218 -----------------------------------QAKHMHNHHNIQPDRPSIQIKVSVRAESKA 247

  Fly   497 AKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRT 561
            ||||:||||..:.||||||:..::.|:: ..:..|.:.....|:|:.|.|:||.|||.:.|.|:.
 Frog   248 AKTLSIVMGVFLFCWLPFFILTIVDPYI-NFSTSEHVYSTVLWLGYFNSALNPIIYALFYPWFQK 311

  Fly   562 AF 563
            .|
 Frog   312 TF 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	64/208 (31%)
		TM helix 1	78..101	CDD:410628	8/24 (33%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	6/21 (29%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	10/22 (45%)
		7tm_GPCRs	<491..563	CDD:475119	29/71 (41%)
		TM helix 6	497..519	CDD:320098	14/21 (67%)
		TM helix 7	531..556	CDD:320098	10/24 (42%)
taar3	XP_004914927.3	7tmA_TAAR2_3_4	23..313	CDD:320437	106/508 (21%)
		TM helix 1	24..50	CDD:320437	8/25 (32%)
		TM helix 2	57..83	CDD:320437	12/25 (48%)
		TM helix 3	95..125	CDD:320437	12/29 (41%)
		TM helix 4	137..160	CDD:320437	5/31 (16%)
		TM helix 5	185..214	CDD:320437	15/190 (8%)
		TM helix 6	242..272	CDD:320437	16/29 (55%)
		TM helix 7	281..306	CDD:320437	10/24 (42%)