Protein Alignment TyrRII and htr5a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_002932543.2
• Gene: htr5a / 100487444
• XenbaseID: XB-GENE-981825
• Length: 351
• Species: Xenopus tropicalis
• Alignment Length: 526
• Identity: 118/526 - (22%)
• Similarity: 188/526 - (35%)
• Gaps: 195/526 - (37%)

  Fly    48 VMATG-AGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNC 111
            |.|.| |||...|....:.:.|       |.:.:..::::.|.:.|.||::.:|..|....|.:.
 Frog    15 VSANGSAGADSWGKHRFSVFSV-------LILTLLAMLVIATFLWNVLVLVTILRVRTFHRVPHN 72

  Fly   112 FVMNLAITDWLVGTCVMPPSVVLYITG-TWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLA 175
            .|.::||:|.:|...|||.|:|..:.. .||.|.:||.||||.|:|.|:.||.::.||:||||.:
 Frog    73 LVASMAISDVMVAALVMPLSLVHELNDRRWRLGRVLCHIWISFDVLCCTASIWNVTAIALDRYWS 137

  Fly   176 VTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSA 240
            :|:.|.|:.|.| ||::.:|||:.|:.:..|:..|..||.|......|  :|:.:|...|.:||.
 Frog   138 ITRHLEYTLKTR-KRISNIMILLTWLLSAVISLSPLFGWGETYSEVNE--ECQVSQEPSYTIFST 199

  Fly   241 MGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPN 305
            .|:|::||.|:|:||                                              |...
 Frog   200 FGAFYLPLCVVLFVY----------------------------------------------WKIY 218

  Fly   306 RKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPT 370
            :.:::|..|                                             .||.|....|.
 Frog   219 KAAKFRIGS---------------------------------------------KKTNTITPMPE 238

  Fly   371 FYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTV 435
            ..|:.|.|....::.                                           |....||
 Frog   239 VIEVKEASHQPQMVF-------------------------------------------TVRHATV 260

  Fly   436 ALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTL 500
            ..:|:.....|.|:|                                            |.|..:
 Frog   261 TFQTDGDTWREQKEK--------------------------------------------KAALMV 281

  Fly   501 TIVMGGLIACWLPFFVYYLLIPF--LPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF 563
            .|::|..:.||:|||:..|:.|.  ...|.:.:.:   |.|:|:.|...||.||..:|.::..||
 Frog   282 GILIGVFVLCWIPFFITELINPLCSCDIPPIWKSI---FLWLGYSNSFFNPLIYTAFNKNYNNAF 343

  Fly   564 WRLTCR 569
            ..|..|
 Frog   344 RNLFSR 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	67/192 (35%)
		TM helix 1	78..101	CDD:410628	4/22 (18%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	5/15 (33%)
		TM helix 5	233..256	CDD:410628	10/22 (45%)
		7tm_GPCRs	<491..563	CDD:475119	21/73 (29%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
htr5a	XP_002932543.2	7tmA_5-HT5	36..343	CDD:320451	107/497 (22%)
		TM helix 1	37..63	CDD:320451	6/25 (24%)
		TM helix 2	70..96	CDD:320451	10/25 (40%)
		TM helix 3	109..139	CDD:320451	16/29 (55%)
		TM helix 4	151..172	CDD:320451	6/20 (30%)
		TM helix 5	191..220	CDD:320451	12/74 (16%)
		TM helix 6	272..302	CDD:320451	12/73 (16%)
		TM helix 7	311..336	CDD:320451	8/27 (30%)