Protein Alignment TyrRII and drd4

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_002937535.2
• Gene: drd4 / 100486482
• XenbaseID: XB-GENE-990215
• Length: 414
• Species: Xenopus tropicalis
• Alignment Length: 499
• Identity: 124/499 - (24%)
• Similarity: 196/499 - (39%)
• Gaps: 150/499 - (30%)

  Fly    76 LAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVL-YITGT 139
            ||:....::|:..:.||.||.|:|.|.:.|:|.||.|:::||:.|.|:...|:|..|.. ::.|.
 Frog    64 LALVFGFILIVCIICGNVLVCLSVCTEKALKTTTNYFIVSLAVADLLLAVLVLPLYVYTEFVGGV 128

  Fly   140 WRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITAL 204
            |....:|||:.:::|::||:.||.:|||||:||::||:.||.|::::...| .|.:|...||.|.
 Frog   129 WTLSLVLCDVLMTMDVMLCTASIFNLCAISVDRFIAVSIPLNYNRRQVDNR-QLFLISTTWIFAF 192

  Fly   205 SITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRI 269
            ::..|...|...|.......  |:...| .|:|:|::.|||||..:||.:|..:.:.|
 Frog   193 AVASPVIFGLNNVADRDPTM--CKLEDN-NYIVYSSVCSFFIPCPIMLVLYCAMFHGL------- 247

  Fly   270 VRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQS- 333
                                          .||...||::.|                  .|.|
 Frog   248 ------------------------------RKWEETRKTKLR------------------SHMSP 264

  Fly   334 SVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCM 398
            .:|..:|                    ..|.....||..:|.|::....            |.|
 Frog   265 GLKPPQC--------------------PALLLDRSPTDSKLDELNLYDQ------------GDC- 296

  Fly   399 HSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHP 463
               |....|               |.|.....|.....|:.:..:|.|.||
 Frog   297 ---PFPKSY---------------VDNGHGIQTVAYPHLKYSTNMEPERKQ-------------- 329

  Fly   464 HAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPA 528
             |..:|                      |:.|..:.|.:|:|..:.||.||||.::.........
 Frog   330 -AKING----------------------RERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCY 371

  Fly   529 VLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPIC 572
            :.|.|:...||:|:||.|:||.||..:|.:||. ::|...|..|
 Frog   372 IPEQLISIVTWLGYVNSALNPVIYTIFNTEFRN-YFRKVLRVCC 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	65/192 (34%)
		TM helix 1	78..101	CDD:410628	7/22 (32%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	10/22 (45%)
		7tm_GPCRs	<491..563	CDD:475119	26/71 (37%)
		TM helix 6	497..519	CDD:320098	9/21 (43%)
		TM helix 7	531..556	CDD:320098	12/24 (50%)
drd4	XP_002937535.2	7tmA_D4_dopamine_R	63..406	CDD:320434	121/489 (25%)
		TM helix 1	64..90	CDD:320434	9/25 (36%)
		TM helix 2	97..123	CDD:320434	10/25 (40%)
		TM helix 3	136..166	CDD:320434	15/29 (52%)
		TM helix 4	178..201	CDD:320434	7/23 (30%)
		TM helix 5	217..246	CDD:320434	12/29 (41%)
		TM helix 6	334..364	CDD:320434	12/51 (24%)
		TM helix 7	374..399	CDD:320434	12/24 (50%)