Protein Alignment TyrRII and adra2b

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_002932610.1
• Gene: adra2b / 100485811
• XenbaseID: XB-GENE-999343
• Length: 410
• Species: Xenopus tropicalis
• Alignment Length: 499
• Identity: 143/499 - (28%)
• Similarity: 219/499 - (43%)
• Gaps: 114/499 - (22%)

  Fly    75 SLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGT 139
            ::..|:...::|.|:.||.|||:||||:|.|:...|.|:::||..|.||.|.::|.|:...:.|.
 Frog    13 AVIAAIITFLVLFTIFGNVLVIIAVLTSRSLKAPQNLFLVSLAAADILVATLIIPFSLANELMGY 77

  Fly   140 WRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITAL 204
            |.||...|:::::||:|.|:.||:.|||||||||.:|:|.:.|:.||..||:..: ||:||..|.
 Frog    78 WYFGKTWCEMYLALDVLFCTSSIVHLCAISLDRYWSVSQAIEYNSKRTPKRIKCI-ILIVWTLAA 141

  Fly   205 SITCPP--YLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQ 267
            .|:.||  |.|   ..:.|....:|:.|:...|::.|::.|||.|..:|:.||::| |::..||.
 Frog   142 LISLPPLIYKG---KSKDQNAKPECKLNEEPWYILSSSICSFFAPCLIMILVYLRI-YLIAKRRN 202

  Fly   268 RIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQ 332
            |       :.:.|..:                .|..|...||...:||:
 Frog   203 R-------KNSTDKKL----------------KKMAPGLFSRTNKHSLN---------------- 228

  Fly   333 SSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPC 397
            ||...::|...||...|     |..:.|                       :||       |.|.
 Frog   229 SSHTQTQCGIISSQEKT-----GLALDD-----------------------LHC-------GVPV 258

  Fly   398 MHSTPSGMHYVGTEASFSDTCLGGNV--SNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDH 460
            :.||....:  |...||.....|.|:  :|.......:|||  |.:.:....|..:....||
 Frog   259 LSSTREERN--GHSESFGLQPQGENLKHTNGCEPAVMDTVA--TVKGVMLMPKGAKDSDLSS--- 316

  Fly   461 HHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLP 525
                                   ..:.|...|:.:....|.:|:|..:.||.|||..|.|.....
 Frog   317 -----------------------AKKKSYINREKRFTFVLAVVIGVFVLCWFPFFFTYSLGAICT 358

  Fly   526 RPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLTC 568
            ....:.|.:|. |.|||:.|.::||.||..:|.|||.||.|:.|
 Frog   359 ELCYIPDSVFQFFFWIGYCNSSLNPVIYTIFNQDFRKAFRRILC 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	78/193 (40%)
		TM helix 1	78..101	CDD:410628	10/22 (45%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	6/15 (40%)
		TM helix 5	233..256	CDD:410628	8/22 (36%)
		7tm_GPCRs	<491..563	CDD:475119	26/72 (36%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	11/25 (44%)
adra2b	XP_002932610.1	7tmA_alpha2B_AR	7..397	CDD:320444	139/492 (28%)
		TM helix 1	14..40	CDD:320444	11/25 (44%)
		TM helix 2	47..73	CDD:320444	10/25 (40%)
		TM helix 3	85..115	CDD:320444	16/29 (55%)
		TM helix 4	127..150	CDD:320444	10/23 (43%)
		TM helix 5	168..197	CDD:320444	11/29 (38%)
		TM helix 6	324..354	CDD:320444	10/29 (34%)
		TM helix 7	365..390	CDD:320444	11/24 (46%)