Protein Alignment TyrRII and adra2c

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001120375.1
• Gene: adra2c / 100145449
• XenbaseID: XB-GENE-5773399
• Length: 433
• Species: Xenopus tropicalis
• Alignment Length: 516
• Identity: 140/516 - (27%)
• Similarity: 224/516 - (43%)
• Gaps: 134/516 - (25%)

  Fly    72 WPKSL-------AVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMP 129
            ||.|:       |:..||:|.  |:|||..|::||||:|.|:...|.|:::||..|.||...|||
 Frog    24 WPYSMTSVWCLAAIVGFLIIF--TIVGNVFVVIAVLTSRALKAPQNLFLVSLASADILVAALVMP 86

  Fly   130 PSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALL 194
            .|:...:.|.|.||.:.|||:::||:|.|:.||:.|||||||||.:|||.:.|:.||..:|:..:
 Frog    87 FSLANELMGYWYFGNVWCDIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRIKGI 151

  Fly   195 MILVVWITALSITCPPYLGWYEVGRHQAE--FVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVK 257
             |:.||:.:..|:.||.:   .:.|...:  :..|:.|.:..|::.|.:||||.|..:|:.||::
 Frog   152 -IVTVWLISAVISFPPLI---SMDRDTEDDVYPQCKLNDDTWYILSSCIGSFFAPCIIMILVYIR 212

  Fly   258 IGYVLTSRRQRIVRDAYSERTADYDVDGDNFIS---------ESEHYHCTPTKWLPNRKSRWRFN 313
            | |.:...|.|.:.:  .:.|.|.....:|..|         :.|:.||.|      |.|
 Frog   213 I-YQVAKLRTRTLSE--KKPTRDGSSHTENGFSKGTTVKMPGDKENGHCPP------RPS----- 263

  Fly   314 SLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVS 378
                 ||.|......:..:||:..||..|.||...
 Frog   264 -----PPKATDVEDLELEESSMSESKRRKSSSKED------------------------------ 293

  Fly   379 RLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKL 443
                                          .|::|....|..||..:..::..:.|    :|:.:
 Frog   294 ------------------------------NTDSSKERKCSKGNSFSKQSSRLSRT----SNKSM 324

  Fly   444 EAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLI 508
            |..:.:|::::.|                          :..|..:..|:.:....|.:|||..:
 Frog   325 ELFSSRKKKKRSS--------------------------VSRRKLSQAREKRFTFVLAVVMGVFV 363

  Fly   509 ACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLTC 568
            .||.|||..|.|.........:.:.:|. |.|||:.|.::||.||..:|.|||.:|.::.|
 Frog   364 VCWFPFFFSYSLYGICREACEVPETLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSFKKIIC 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	77/193 (40%)
		TM helix 1	78..101	CDD:410628	10/22 (45%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	12/21 (57%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	9/22 (41%)
		7tm_GPCRs	<491..563	CDD:475119	26/72 (36%)
		TM helix 6	497..519	CDD:320098	9/21 (43%)
		TM helix 7	531..556	CDD:320098	10/25 (40%)
adra2c	NP_001120375.1	7tmA_alpha2C_AR	32..419	CDD:320446	135/501 (27%)
		TM helix 1	33..59	CDD:320446	12/27 (44%)
		TM helix 2	66..92	CDD:320446	11/25 (44%)
		TM helix 3	104..134	CDD:320446	18/29 (62%)
		TM helix 4	146..169	CDD:320446	7/26 (27%)
		TM helix 5	187..216	CDD:320446	12/29 (41%)
		TM helix 6	346..376	CDD:320446	11/29 (38%)
		TM helix 7	387..412	CDD:320446	10/24 (42%)