Protein Alignment TyrRII and adrb2b

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001082940.3
• Gene: adrb2b / 100037315
• ZFINID: ZDB-GENE-070410-32
• Length: 409
• Species: Danio rerio
• Alignment Length: 534
• Identity: 120/534 - (22%)
• Similarity: 182/534 - (34%)
• Gaps: 227/534 - (42%)

  Fly    73 PKSLAVAVFL------------VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGT 125
            |.||:|:.:.            :::||.|.||.|||.|::..:||:||||.|:.:||..|.::|.
Zfish    27 PVSLSVSEYSDAEVVLISILIGILVLVIVFGNALVISAIVRFQRLQTVTNYFISSLACADLVMGL 91

  Fly   126 CVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKR 190
            .|:|......:..||.||...|:.|.:.|:|..:.||.:||.|:||||:|:..||.| :...:||
Zfish    92 MVVPFGACYILLNTWHFGNFFCEFWTATDVLCVTASIETLCVIALDRYIAIMWPLRY-QSMLTKR 155

  Fly   191 LALLMILVVW-ITALSITCPPYLGWYEVGRHQA-----EFVDCRYNQNKGYVVFSAMGSFFIPLT 249
            .|..|::.|| :.||....|.::.|:.....:|     |...|.:|.|..|.|.|::.||:|||.
Zfish   156 KACGMVIGVWAVAALISFLPIHMEWWVSDEPEALSCLEEPTCCDFNTNAAYAVTSSIISFYIPLV 220

  Fly   250 VMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNS 314
            :|.:||.::  ...:|||
Zfish   221 IMAFVYSRV--FQEARRQ----------------------------------------------- 236

  Fly   315 LHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSR 379
                                                                       |.::.|
Zfish   237 -----------------------------------------------------------LQKIDR 242

  Fly   380 LSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLE 444
            :...|...::|.:.|.
Zfish   243 IEGRIRTQSLSTQEGN------------------------------------------------- 258

  Fly   445 AEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIA 509
             |.|.:                                   |.....:|.|..|||.|:||....
Zfish   259 -EIKNR-----------------------------------RTKFCMKDHKALKTLGIIMGTFTL 287

  Fly   510 CWLPFFVYYLLIPFLPRPAVLEDLMFGF---TWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPI 571
            |||||||..::.....    ::::|..|   .|||:.|.|.||.||. .:|:||.||..:.|
Zfish   288 CWLPFFVLNVVAAIWK----MDNIMLPFRILNWIGYANSAFNPLIYC-RSPEFRCAFQEILC--- 344

  Fly   572 CKQKRPPNHLAMFR 585
                ..|:||...|
Zfish   345 ----WRPSHLPSTR 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	73/209 (35%)
		TM helix 1	78..101	CDD:410628	10/34 (29%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	8/21 (38%)
		TM helix 4	194..210	CDD:410628	5/16 (31%)
		TM helix 5	233..256	CDD:410628	10/22 (45%)
		7tm_GPCRs	<491..563	CDD:475119	29/74 (39%)
		TM helix 6	497..519	CDD:320098	13/21 (62%)
		TM helix 7	531..556	CDD:320098	11/27 (41%)
adrb2b	NP_001082940.3	None