Protein Alignment TyrRII and htr1fb

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_005159986.2
• Gene: htr1fb / 100004819
• ZFINID: ZDB-GENE-090312-140
• Length: 372
• Species: Danio rerio
• Alignment Length: 527
• Identity: 132/527 - (25%)
• Similarity: 207/527 - (39%)
• Gaps: 187/527 - (35%)

  Fly    63 MNSYLVSMAWPKSLAVAVFLVIILV-TVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTC 126
            ::..|.|...|..:.:::.|..:.| |...|:|||.|:|.||:|....|..:.:||:||.||...
Zfish    11 LSDVLASKMSPSKILLSLTLSFLAVATTAINSLVITAILITRKLHQPANYLICSLAVTDLLVAVL 75

  Fly   127 VMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRL 191
            |||.|:|.....||..|.|:|.:|:.:|:..|:.|||.|.||:||||.|:|..:.||:||..||
Zfish    76 VMPVSIVYIAEETWVLGPIVCHLWLGVDVTCCTCSILHLAAIALDRYRAITDAVAYSQKRTYKR- 139

  Fly   192 ALLMILVVWITALSITCPPYLGW-------YEVGRHQAEFVDCRY-NQNKGYVVFSAMGSFFIPL 248
            |::.||.:|..::.::.|| |.|       ::.|:.  |.:||.. :.:..:.|:|..|:|:|||
Zfish   140 AIVTILSLWTLSILVSLPP-LVWRKFPKVEFKDGKR--EPMDCLIEHDHVAFTVYSTFGAFYIPL 201

  Fly   249 TVMLYVYVKI---GYVLTSRR--QRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKS 308
            .::|.:|.||   ..:|.:||  .|:|:...|                        :..||...|
Zfish   202 ALILVLYYKIYKAAEMLRNRRGSSRLVKQTVS------------------------SVMLPGMSS 242

  Fly   309 RWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYE 373
                                                               ||.:..
Zfish   243 ---------------------------------------------------DKDIAL-------- 248

  Fly   374 LVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALE 438
                                       :|..  :...|.||||....|. ....|:::.|.:.:.
Zfish   249 ---------------------------SPDS--FCPIEKSFSDPSTDGE-RVRITSSSGNLIRVR 283

  Fly   439 TNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIV 503
            .|                      |.|                          |:.:.|.||.::
Zfish   284 RN----------------------PGA--------------------------RERRAALTLGLI 300

  Fly   504 MGGLIACWLPFFVYYLLIPFLP---RPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWR 565
            :|..:.||||||:..:::...|   ..|||.|.:   ||:|::|..|||.||..:|.||:.||.:
Zfish   301 LGAFVVCWLPFFLKEVIVNICPTCTTSAVLADFL---TWLGYLNSLINPLIYTIFNEDFKKAFKK 362

  Fly   566 LTCRPIC 572
            |.  |:|
Zfish   363 LL--PLC 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	77/205 (38%)
		TM helix 1	78..101	CDD:410628	8/23 (35%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	9/21 (43%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	8/22 (36%)
		7tm_GPCRs	<491..563	CDD:475119	28/74 (38%)
		TM helix 6	497..519	CDD:320098	10/21 (48%)
		TM helix 7	531..556	CDD:320098	10/24 (42%)
htr1fb	XP_005159986.2	None