Protein Alignment TyrRII and htr1aa

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001116793.1
• Gene: htr1aa / 100001828
• ZFINID: ZDB-GENE-071203-1
• Length: 398
• Species: Danio rerio
• Alignment Length: 499
• Identity: 140/499 - (28%)
• Similarity: 205/499 - (41%)
• Gaps: 140/499 - (28%)

  Fly    79 AVFL-VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRF 142
            ::|| .:||..::||..||.|:...|.|:.|.|..:.:||:||.:|...|:|.:.:..:...|..
Zfish    32 SLFLAALILFAILGNACVIAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTL 96

  Fly   143 GWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSIT 207
            |..:|||:||||:|.|:.|||.||||:||||.|:|.|:.|..||..:|.|:| |.:.|:...||:
Zfish    97 GQEMCDIFISLDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAIL-ISLTWLIGFSIS 160

  Fly   208 CPPYLGWYEVGRHQAEFVD---CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRI 269
            .||.|||    |...:..|   |..:|:.||.::|..|:|:|||.:||.:|.:|......|.::.
Zfish   161 IPPMLGW----RKPEDRADPDACTISQDHGYTIYSTFGAFYIPLILMLVLYGRIFRAARFRIRKT 221

  Fly   270 VRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSS 334
            |:.....:.||
Zfish   222 VKKTEKAKIAD------------------------------------------------------ 232

  Fly   335 VKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMH 399
                ||...|.|.....|.   |.|.||.....:|                     |..|  .:.
Zfish   233 ----KCLAVSPALFPRKAN---GEVGKTWRRSVEP---------------------CANG--ALK 267

  Fly   400 STPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTN-TVALETNEKLEAEAKQKQQQQRSSFDHHHP 463
            ::..|..:..||..        ::|.|..:...| ....|...:...|||:|
Zfish   268 NSDDGESFEITEVQ--------SISKNHLSLPNNPQPCFENRNEKNTEAKRK------------- 311

  Fly   464 HAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPA 528
                                    ....|:.||.|||.|:||..|.||||||:..|::||.....
Zfish   312 ------------------------VALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCQDCF 352

  Fly   529 VLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWR-LTCRPI 571
            :.|.|.....|:|:.|..:||.|||::|.||:.||.: |.|:.|
Zfish   353 MPEWLGAVINWLGYSNSLLNPVIYAYFNKDFQNAFKKILKCKCI 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	77/194 (40%)
		TM helix 1	78..101	CDD:410628	9/22 (41%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	15/21 (71%)
		TM helix 4	194..210	CDD:410628	5/15 (33%)
		TM helix 5	233..256	CDD:410628	10/22 (45%)
		7tm_GPCRs	<491..563	CDD:475119	32/71 (45%)
		TM helix 6	497..519	CDD:320098	13/21 (62%)
		TM helix 7	531..556	CDD:320098	10/24 (42%)
htr1aa	NP_001116793.1	7tm_GPCRs	29..387	CDD:475119	135/488 (28%)
		TM helix 1	31..55	CDD:410628	9/22 (41%)
		TM helix 2	64..86	CDD:410628	8/21 (38%)
		TM helix 3	102..124	CDD:410628	15/21 (71%)
		TM helix 4	147..163	CDD:410628	5/16 (31%)
		TM helix 5	185..208	CDD:410628	10/22 (45%)
		TM helix 6	321..343	CDD:410628	13/21 (62%)
		TM helix 7	355..380	CDD:410628	10/24 (42%)