Protein Alignment TyrRII and htr2cl1

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_073762008.1
• Gene: htr2cl1 / 100000981
• ZFINID: ZDB-GENE-081104-48
• Length: 531
• Species: Danio rerio
• Alignment Length: 611
• Identity: 144/611 - (23%)
• Similarity: 214/611 - (35%)
• Gaps: 222/611 - (36%)

  Fly    43 APGGDVMATGAGAGKLGVPSMNSYLVS---MAWPKSLAVA------------------------- 79
            ||||.|:.        |..|..|.|..   |.||.:..|:
Zfish     4 APGGPVLG--------GFSSTTSSLDLVGWMIWPGNTTVSLNQSFFGTDYSFNLSSSSSSSPHGV 60

  Fly    80 -------------VFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPS 131
                         :.||||::|:.||.||||||...::|:..||.|:.:||:.|.|||..|||.|
Zfish    61 KREEMKEKNWPALLILVIIILTIGGNILVILAVSLEKKLQNATNFFLRSLAVADMLVGILVMPIS 125

  Fly   132 V--VLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALL 194
            :  :|| ...|.....||.|||.||:|..:.||:.|||||||||:|:..|:.:| :..|:..|:|
Zfish   126 LINILY-DYAWPLPSALCPIWIYLDVLFSTASIMHLCAISLDRYVAIRNPIEHS-RFNSRTKAML 188

  Fly   195 MILVVWI---------------TALSITCPPYLGWYEVGRHQAEFV----DCRYNQNKGYVVFSA 240
            .|..||.               |.:|:..|      .:|....|.|    .|..|:.. :::..:
Zfish   189 KIAAVWTISIGQRNTDLMILSKTGISMPIP------VIGLSNREKVLKNGICALNEEL-FILVGS 246

  Fly   241 MGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPN 305
            ..:|||||.:|:..|...  |...:||..|                 |:.|.:.....|.:  |.
Zfish   247 FVAFFIPLVIMVVTYCLT--VQALQRQATV-----------------FLYEGKASSQQPLQ--PP 290

  Fly   306 RKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPT 370
            .           ||.|......|...:||:.|.:.|.....|      .|..|...|:
Zfish   291 A-----------PPSSQLVPPLAPSRRSSLNCLRISNSDGNT------LGLTVPPDTI------- 331

  Fly   371 FYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTV 435
                       |:|..|.      .|...::|:|....|.
Zfish   332 -----------SIIPSSE------APSQMNSPAGRDPAGA------------------------- 354

  Fly   436 ALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTL 500
                                            ||..|.             :...|.:.:.:|.|
Zfish   355 --------------------------------HGRRGM-------------MQAIKNERRASKVL 374

  Fly   501 TIVMGGLIACWLPFF---VYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTA 562
            .:|....:..|.|||   |.|:|.....:..:|.:|:..|.|:|:::..:||.:|..:|..:|.|
Zfish   375 GVVFFLFLFMWCPFFITNVLYVLCHRTCKETLLTELLNVFVWVGYISSGVNPLVYTLFNKTYRRA 439

  Fly   563 FWR-LTC-------RPICKQKRPPNH 580
            |.. :.|       :||......|:|
Zfish   440 FSNYMHCQYRHVGLKPITINVPCPSH 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	77/250 (31%)
		TM helix 1	78..101	CDD:410628	14/60 (23%)
		TM helix 2	110..132	CDD:410628	11/21 (52%)
		TM helix 3	148..170	CDD:410628	12/21 (57%)
		TM helix 4	194..210	CDD:410628	6/30 (20%)
		TM helix 5	233..256	CDD:410628	6/22 (27%)
		7tm_GPCRs	<491..563	CDD:475119	21/74 (28%)
		TM helix 6	497..519	CDD:320098	8/24 (33%)
		TM helix 7	531..556	CDD:320098	7/24 (29%)
htr2cl1	XP_073762008.1	None