DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr1 and LGR5

DIOPT Version :10

Sequence 1:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster
Sequence 2:NP_003658.1 Gene:LGR5 / 8549 HGNCID:4504 Length:907 Species:Homo sapiens


Alignment Length:770 Identity:181/770 - (23%)
Similarity:333/770 - (43%) Gaps:132/770 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LHHL-----LLTSLSGRHFVYATSAVGGALSANNCHDI-HHGFDVYPNLTAVSLAQSTDTPLTAT 92
            |.||     .||.:..:.|...::.....|:.|..|.| .:.|....:|..:.|           
Human   164 LRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHL----------- 217

  Fly    93 MPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRL---TIASAGLPRLRHTGLK--- 151
                        .:|:...:..:| .|||:.: :||.|....|   ..|...|..|:..|..   
Human   218 ------------HNNRIHSLGKKC-FDGLHSL-ETLDLNYNNLDEFPTAIRTLSNLKELGFHSNN 268

  Fly   152 ---------VYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDT 207
                     |...:|:.:.|.| ..::.:...||.:|..|||:.:..|.::|     .|..::.|
Human   269 IRSIPEKAFVGNPSLITIHFYD-NPIQFVGRSAFQHLPELRTLTLNGASQIT-----EFPDLTGT 327

  Fly   208 VDI--IRIINSGLTRVPD--LGHLPPHNILQMIDLDNNQITRIDSKSIKVKTAQLILTNNEISYV 268
            .::  :.:..:.::.:|.  ...||.   ||::||..|.:..:.|.|:..|..::.|.:|||..:
Human   328 ANLESLTLTGAQISSLPQTVCNQLPN---LQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEI 389

  Fly   269 DDSAFFG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNT 332
            ....|.. ..:..|:|..| |:.::|||||..:..:.:|||||..|...|..||..:..|.:...
Human   390 KVDTFQQLLSLRSLNLAWN-KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGN 453

  Fly   333 HTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEI-EKWRKQCKSDSGTRKER 396
            |.|:::.|..||..|:...:.:::.||||..         .:...:| .:|.|         .:.
Human   454 HALQSLISSENFPELKVIEMPYAYQCCAFGV---------CENAYKISNQWNK---------GDN 500

  Fly   397 STLDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCG 461
            |::|:...  :|.|.|...|:...:         |::.|...:....|                 
Human   501 SSMDDLHK--KDAGMFQAQDERDLE---------DFLLDFEEDLKALH----------------- 537

  Fly   462 NFTFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRF 526
                   :::|.|.|....|||.::....:||.||.:..||:..|..|.:.:.......:|: :.
Human   538 -------SVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPI-KL 594

  Fly   527 LMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVIT 591
            |:..:|..::..|:...::|.:||.:.|.:......|:.|:||.|.|||::|||..|||.||:..
Human   595 LIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAA 659

  Fly   592 IERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTI 656
            :||..::..:.....:.......:|:|...:.::.|:::||.|.|.|.::.:|||:...:.....
Human   660 LERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMG 724

  Fly   657 YLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGEL------SVAKKMALLVFTNFACW 715
            |::|::..|.:.|.::.:.|.::|.:|.:          |:|      |:.|.:|||:|||....
Human   725 YMVALILLNSLCFLMMTIAYTKLYCNLDK----------GDLENIWDCSMVKHIALLLFTNCILN 779

  Fly   716 SPIAFFGLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTL 770
            .|:||...::|.....|:....|.:|:...||.:|.:|.||.:....:::||.:|
Human   780 CPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSL 834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr1NP_524393.2 LRR <162..>354 CDD:443914 53/196 (27%)
leucine-rich repeat 182..207 CDD:275380 6/24 (25%)
leucine-rich repeat 208..231 CDD:275380 3/26 (12%)
leucine-rich repeat 233..256 CDD:275380 8/22 (36%)
leucine-rich repeat 257..277 CDD:275380 5/20 (25%)
leucine-rich repeat 278..302 CDD:275380 9/23 (39%)
leucine-rich repeat 303..323 CDD:275380 9/19 (47%)
leucine-rich repeat 324..346 CDD:275380 6/21 (29%)
7tmA_Glyco_hormone_R 490..767 CDD:320264 75/282 (27%)
TM helix 1 490..516 CDD:320264 8/25 (32%)
TM helix 2 524..549 CDD:320264 4/24 (17%)
TM helix 3 569..599 CDD:320264 15/29 (52%)
TM helix 4 611..633 CDD:320264 4/21 (19%)
TM helix 5 653..682 CDD:320264 6/28 (21%)
TM helix 6 692..725 CDD:320264 13/38 (34%)
TM helix 7 735..760 CDD:320264 8/24 (33%)
LGR5NP_003658.1 LRRNT 33..65 CDD:396168
leucine-rich repeat 68..91 CDD:275380
LRR 92..477 CDD:443914 81/347 (23%)
leucine-rich repeat 92..115 CDD:275380
leucine-rich repeat 116..139 CDD:275380
leucine-rich repeat 140..163 CDD:275380
leucine-rich repeat 164..187 CDD:275380 6/22 (27%)
leucine-rich repeat 188..211 CDD:275380 5/22 (23%)
leucine-rich repeat 212..235 CDD:275380 7/46 (15%)
leucine-rich repeat 236..258 CDD:275380 6/22 (27%)
leucine-rich repeat 259..282 CDD:275380 3/22 (14%)
leucine-rich repeat 283..304 CDD:275380 5/21 (24%)
leucine-rich repeat 307..353 CDD:275378 9/50 (18%)
leucine-rich repeat 354..375 CDD:275378 7/20 (35%)
leucine-rich repeat 376..389 CDD:275378 4/12 (33%)
leucine-rich repeat 400..423 CDD:275378 9/23 (39%)
leucine-rich repeat 445..459 CDD:275378 3/13 (23%)
7tmA_LGR5 558..831 CDD:320485 75/283 (27%)
TM helix 1 559..585 CDD:320485 8/25 (32%)
TM helix 2 592..617 CDD:320485 4/25 (16%)
TM helix 3 637..667 CDD:320485 15/29 (52%)
TM helix 4 679..701 CDD:320485 4/21 (19%)
TM helix 5 721..750 CDD:320485 6/28 (21%)
TM helix 6 759..789 CDD:320485 11/29 (38%)
TM helix 7 799..824 CDD:320485 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

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