Protein Alignment Lgr1 and rxfp2a

DIOPT Version :10

• Sequence 1: NP_524393.2
• Gene: Lgr1 / 42133
• FlyBaseID: FBgn0016650
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: XP_068079928.2
• Gene: rxfp2a / 792884
• ZFINID: ZDB-GENE-040426-1225
• Length: 755
• Species: Danio rerio
• Alignment Length: 807
• Identity: 172/807 - (21%)
• Similarity: 319/807 - (39%)
• Gaps: 201/807 - (24%)

  Fly    62 NCHDIHHGFDVYPNLTAVSLAQSTDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQ 126
            :|.|.....|::..  .:..|:..|.|....:.:....|.|       ::.|..|....|:.||
Zfish    77 HCGDNSGWADIFDR--TIKKAEPQDLPNDCYLQQYPQSCSC-------KKTEVECVDVNLHVVP- 131

  Fly   127 TLTLPIQRLTIASAGLPRLRHTGLKVYGS-TLLDVAFTDCLQLELIQDGAFANLTLLRTIYIT-- 188
               :....:|..|....|:|:....::.. |.:...|.....:|.:...||:.|..|:.::::
Zfish   132 ---ILSSNVTWLSLKNNRIRNLDDYIFSKYTQMQRLFLQNNIIETVSSRAFSRLFTLQRLFLSQN 193

  Fly   189 -----------NAPKLTFL----------SKDVFLGISDTVDIIRIINSGLTRVPDLG---HLPP 229
                       :..||.:|          ::|.|:|:. ::..:.::|..|.|:|:..   |:|
Zfish   194 NITYLGPGVFRDLHKLDWLVLDHNPLKHITRDTFIGLR-SLTYLSMVNVSLMRLPNSSLCQHMP- 256

  Fly   230 HNILQMIDLDNNQITRIDSKSIKVKTAQLILTNNEISYVDDSAFFGSKIAKLSLKENKKLQMMHP 294
              :|..:|...|.:..::..::...|...:||.::                      ..::.:..
Zfish   257 --LLTWLDFAENDVELLNYSTLMTCTELTVLTFHD----------------------NNIKTLPE 297

  Fly   295 NAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCC 359
            |.|..:..:.|||||...:..||.              :|.|::      :.|::..::|:
Zfish   298 NTFHSLGSLAELDLSCNRISKLPK--------------NTFKSL------KYLKKLNISHN---- 338

  Fly   360 AFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPEDFGSFGGTDDSATDITP 424
                |..|....|...::::     |..|..|       ::.|....:.|...|       :::.
Zfish   339 ----PLLHIHTGHFDHLVQL-----QSLSLEG-------IEIPNITTKMFLPMG-------NLSH 380

  Fly   425 ITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNI-ECYPMPNDLNPCEDVMGY 488
            |.|..|.|.:                               ..|:: :|.|..:.::..||::..
Zfish   381 IYFKDFQYCS-------------------------------YAPHVRKCKPNTDGISSVEDLLAS 414

  Fly   489 QWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCH------LAFADLCLGLYLLLVAC 547
            ..||:|||::..:...||:.|:.:...||.|:.       .|      |.|||..:|:||..:..
Zfish   415 LVLRVSVWVMAFITCFGNLFVIGMRSFIRAENN-------LHAACIKVLCFADCLMGVYLFFLGI 472

  Fly   548 IDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLRP 612
            .|....|||...|..|...:.|:..|||.:.:|.:||..||.:|:|::|.|  ....:|   |||
Zfish   473 FDVKFRGEYNRNALIWMDSVECRTIGFLAMLSSEVSVLLLTYLTLEKFLVI--VFPFSH---LRP 532

  Fly   613 A----ALIMLGGWIYSMLMSSLP-----LFGISNYSSTSICLPMENRDV-------YDT-IYLIA 660
            |    .||:...|....:::::|     ||| :.|....:|.|:.:..:       |.| |:
Zfish   533 AKLQTVLILAFIWFLGFVIAAVPLLNEDLFG-NYYGRNGVCFPLHSDRLEKPTAKGYSTGIF--- 593

  Fly   661 ILGSNGVAFSIIAVCYAQIYLSL---GRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFG 722
             ||.|.|||.:|.:.|:.::.|:   |............:::||.:...:||::..||.||....
Zfish   594 -LGLNLVAFLVIVISYSSMFCSIYKTGINATDVRSRLHKDVAVANRFFFIVFSDALCWIPIFLVK 657

  Fly   723 LTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLC---QQSALKY 784
            ..:|....:.....|.: ::|..|:||..:|.||.:.||.:|:.:     :|.||   ::||.|
Zfish   658 TLSLMKVEIPGTINSWV-VIFILPINSALNPILYTLTTSFFREQV-----ELLLCRWQRRSATK- 715

  Fly   785 KDSLSGQATTRFTIHGSIQRHSSLTCK 811
            ||.   ::.|..||:....|:.....|
Zfish   716 KDR---KSVTSSTIYMETSRNPEYPAK 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	LRR	<162..>354	CDD:443914	36/217 (17%)
		leucine-rich repeat	182..207	CDD:275380	7/47 (15%)
		leucine-rich repeat	208..231	CDD:275380	6/25 (24%)
		leucine-rich repeat	233..256	CDD:275380	3/22 (14%)
		leucine-rich repeat	257..277	CDD:275380	2/19 (11%)
		leucine-rich repeat	278..302	CDD:275380	2/23 (9%)
		leucine-rich repeat	303..323	CDD:275380	7/19 (37%)
		leucine-rich repeat	324..346	CDD:275380	2/21 (10%)
		7tmA_Glyco_hormone_R	490..767	CDD:320264	86/302 (28%)
		TM helix 1	490..516	CDD:320264	8/25 (32%)
		TM helix 2	524..549	CDD:320264	8/30 (27%)
		TM helix 3	569..599	CDD:320264	12/29 (41%)
		TM helix 4	611..633	CDD:320264	7/30 (23%)
		TM helix 5	653..682	CDD:320264	11/29 (38%)
		TM helix 6	692..725	CDD:320264	8/32 (25%)
		TM helix 7	735..760	CDD:320264	8/24 (33%)
rxfp2a	XP_068079928.2	None