DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and LGR6

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001017403.1	Gene:	LGR6 / 59352	HGNCID:	19719	Length:	967	Species:	Homo sapiens

Alignment Length:	855	Identity:	183/855 - (21%)
Similarity:	331/855 - (38%)	Gaps:	205/855 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLHHLLLTS---LSGRHF----------VYA-------TSAVGGALSANNCHDIHHGFDVYPNLT 77
            |.|||....   |||.|.          :|:       .:.:|| :.|....::       |:|.
Human    85 LFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG-IPAEALWEL-------PSLQ 141

  Fly    78 AVSLAQSTDTPLTATMPRSAWKCC-----CWNASNQAEEVECRCEGDGLNRVP--QTLTLPIQR- 134
            ::.|    |..|.:.:|..:::..     .|...|...|:..|    .||.:|  |.:||.:.|
Human   142 SLRL----DANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR----ALNNLPALQAMTLALNRI 198

  Fly   135 -------------LTIASAGLPRLRHTGLK----VYGSTLLDVAFTDCLQ--------------- 167
                         |.:......|::|.|..    ::....||:.:....:
Human   199 SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELG 263

  Fly   168 -----LELIQDGAFANLTLLRTIYITNAPKLTFLSKDVF--------LGISDTVDI--------- 210
                 ::.|.:.||....||:||:..:.| :.|:.:..|        |.::..:||
Human   264 FHNNNIKAIPEKAFMGNPLLQTIHFYDNP-IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT 327

  Fly   211 ------------IRIINSGLTRVPDLGHLPPHNILQMIDLDNNQITRIDSKSIKVKTAQLILTNN 263
                        ||::.||:.:     .||.   |::::|.:|||..:.|.....|..::.|.:|
Human   328 TSLEILTLTRAGIRLLPSGMCQ-----QLPR---LRVLELSHNQIEELPSLHRCQKLEEIGLQHN 384

  Fly   264 EISYVDDSAFFG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEAL 327
            .|..:....|.. |.:..|.|..| .::.:||.||..:..:.:|||:...|..||.|||..:..|
Human   385 RIWEIGADTFSQLSSLQALDLSWN-AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHL 448

  Fly   328 YIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGT 392
            .::....|....|..:|..|:...:.:::.||
Human   449 KLKGNLALSQAFSKDSFPKLRILEVPYAYQCC--------------------------------- 480

  Fly   393 RKERSTLDNPFNMPEDFGSFGG--------TDDSATDITPITFAS------FDYMADDTMNKGTF 443
                     |:.|...|....|        .||..:...|:...:      :|...|:...:
Human   481 ---------PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLE--- 533

  Fly   444 HEKIILNPGDDSSAELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVA 508
                    .:||...         |:::|.|.|....|||.:.....:|::||.:|.|:|:.|..
Human   534 --------MEDSKPH---------PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL 581

  Fly   509 VLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAG 573
            ||..:.:..|...|..:|::..:|.|:...|:...|:|.:||.:.|::..:...|:.||||:..|
Human   582 VLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATG 646

  Fly   574 FLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNY 638
            ||.|..|..||..||:..::..::::..........|......:||....:.|.::|||..:..|
Human   647 FLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEY 711

  Fly   639 SSTSICLPMENRDVYDTI--YLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVA 701
            .::.:|||....:.....  :.:|::..|...|.::|..|.::|..|.|...:|    ..:.::.
Human   712 GASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEA----VWDCAMV 772

  Fly   702 KKMALLVFTNFACWSPIAFFGLTALAG-YPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQ 765
            :.:|.|:|.:...:.|:||....::.| :|:.......:|||.. ||.:|.:|.||.:....:|.
Human   773 RHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVL-PLPACLNPLLYLLFNPHFRD 836

  Fly   766 DLFTLLSKLG 775
            ||..|..:.|
Human   837 DLRRLRPRAG 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	7/32 (22%)
		leucine-rich repeat	208..231	CDD:275380	8/43 (19%)
		leucine-rich repeat	233..256	CDD:275380	7/22 (32%)
		leucine-rich repeat	257..277	CDD:275380	4/20 (20%)
		LRR_8	258..313	CDD:290566	15/55 (27%)
		leucine-rich repeat	278..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..323	CDD:275380	9/19 (47%)
		leucine-rich repeat	324..346	CDD:275380	4/21 (19%)
		7tm_1	505..756	CDD:278431	63/253 (25%)
LGR6	NP_001017403.1	LRRNT	34..68	CDD:214470
		LRR_RI	<57..199	CDD:238064	29/129 (22%)
		leucine-rich repeat	70..91	CDD:275380	4/5 (80%)
		LRR 1	91..112		4/20 (20%)
		LRR_8	92..150	CDD:290566	12/69 (17%)
		leucine-rich repeat	92..115	CDD:275380	4/22 (18%)
		LRR 2	115..136		3/21 (14%)
		leucine-rich repeat	116..139	CDD:275380	3/30 (10%)
		LRR_RI	131..392	CDD:238064	53/284 (19%)
		LRR 3	139..160		5/24 (21%)
		leucine-rich repeat	140..163	CDD:275380	5/26 (19%)
		LRR 4	163..186		6/26 (23%)
		leucine-rich repeat	164..187	CDD:275380	6/26 (23%)
		LRR_8	186..246	CDD:290566	11/59 (19%)
		LRR 5	187..208		4/20 (20%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		LRR 6	211..232		4/20 (20%)
		leucine-rich repeat	212..235	CDD:275380	4/22 (18%)
		LRR 7	235..256		2/20 (10%)
		leucine-rich repeat	236..258	CDD:275380	2/21 (10%)
		LRR_8	258..314	CDD:290566	11/56 (20%)
		LRR 8	258..279		3/20 (15%)
		leucine-rich repeat	259..282	CDD:275380	3/22 (14%)
		LRR 9	282..303		7/21 (33%)
		leucine-rich repeat	283..304	CDD:275380	6/21 (29%)
		LRR 10	306..328		3/21 (14%)
		LRR 11	329..350		4/25 (16%)
		leucine-rich repeat	330..344	CDD:275378	2/13 (15%)
		LRR 12	353..374		6/23 (26%)
		leucine-rich repeat	354..399	CDD:275380	11/44 (25%)
		LRR_8	375..434	CDD:290566	16/59 (27%)
		LRR 13	375..396		5/20 (25%)
		leucine-rich repeat	376..390	CDD:275378	3/13 (23%)
		LRR 14	399..420		7/21 (33%)
		leucine-rich repeat	400..423	CDD:275380	7/23 (30%)
		LRR 15	423..443		8/19 (42%)
		leucine-rich repeat	424..444	CDD:275380	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810