DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr1 and RXFP1

DIOPT Version :10

Sequence 1:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster
Sequence 2:NP_001240656.1 Gene:RXFP1 / 59350 HGNCID:19718 Length:784 Species:Homo sapiens


Alignment Length:807 Identity:170/807 - (21%)
Similarity:298/807 - (36%) Gaps:262/807 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 PLTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLT--------------LP------- 131
            ||.:.:.....:|.|       :.:|..|:...|..||...:              ||       
Human   119 PLDSVVGSVPVQCLC-------QGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNY 176

  Fly   132 --IQRLTIASAGLPRLRHTGLKVY---GSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAP 191
              :|:|.:.:..:     |.:.:|   |...|...:....::..::.|.|.:|..|..:.|.: .
Human   177 HDLQKLYLQNNKI-----TSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIED-N 235

  Fly   192 KLTFLSKDVFLGISDTVDIIRIINSGLTRVPD---LGHLPPHNILQMIDLDNNQI------TRID 247
            .|:.:|...|.|::..: ::.::|:.|||:||   ..|:|.   |..:||:.|.|      |.|.
Human   236 HLSRISPPTFYGLNSLI-LLVLMNNVLTRLPDKPLCQHMPR---LHWLDLEGNHIHNLRNLTFIS 296

  Fly   248 SKSIKVKTAQLILTNNEISYVDDSAFFG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSST 311
            ..::.|    |::..|:|::::::.|.. .|:.:|.|..| |::.:.|..|..:.::::|:||..
Human   297 CSNLTV----LVMRKNKINHLNENTFAPLQKLDELDLGSN-KIENLPPLIFKDLKELSQLNLSYN 356

  Fly   312 S-----------LVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPS 365
            .           ||.|.|..|:.||...||                                   
Human   357 PIQKIQANQFDYLVKLKSLSLEGIEISNIQ----------------------------------- 386

  Fly   366 RHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFASF 430
                    |||..                                       ...:::.|.|..|
Human   387 --------QRMFR---------------------------------------PLMNLSHIYFKKF 404

  Fly   431 DYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNI-ECYPMPNDLNPCEDVMGYQWLRIS 494
            .|                           ||    ..|:: .|.|..:.::..|:::.....|:.
Human   405 QY---------------------------CG----YAPHVRSCKPNTDGISSLENLLASIIQRVF 438

  Fly   495 VWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNF 559
            ||:|.|:...||:.|:.:...||.|: .:....:..|..||..:|:||.::...|....|||...
Human   439 VWVVSAVTCFGNIFVICMRPYIRSEN-KLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKH 502

  Fly   560 AYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYS 624
            |..|.....|::.|.|.:.::.:||..||.:|:|:::.|..........|.|...:::| .||..
Human   503 AQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITG 566

  Fly   625 MLMSSLPL----FGISNYSSTSICLPMENRD---VYDTIYLIAI-LGSNGVAFSIIAVCYAQIYL 681
            .:::.:||    |..:.|.:..:|.|:.:.|   :...||.:|| ||.|..||.||...|..::.
Human   567 FIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFY 631

  Fly   682 SLGRETRQAHQNS----------PGELSVAKKMALLVFTNFACWSPI---AFFGLTALAGYPLIN 733
            |:       ||::          ..|:.:||:...:|||:..||.||   .|..|..:.    |.
Human   632 SV-------HQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVE----IP 685

  Fly   734 VTKSKILLVFFYPLNSCADPYLYAILTS-----------QYRQ---------------------- 765
            .|.:..:::|..|:||..:|.||.:.|.           .|||                      
Human   686 GTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMW 750

  Fly   766 ------------DLFTLLSKLGLCQQS 780
                        ||||...::.|..||
Human   751 PLQEMPPELMKPDLFTYPCEMSLISQS 777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr1NP_524393.2 LRR <162..>354 CDD:443914 48/212 (23%)
leucine-rich repeat 182..207 CDD:275380 6/24 (25%)
leucine-rich repeat 208..231 CDD:275380 8/25 (32%)
leucine-rich repeat 233..256 CDD:275380 8/28 (29%)
leucine-rich repeat 257..277 CDD:275380 4/20 (20%)
leucine-rich repeat 278..302 CDD:275380 6/23 (26%)
leucine-rich repeat 303..323 CDD:275380 8/30 (27%)
leucine-rich repeat 324..346 CDD:275380 4/21 (19%)
7tmA_Glyco_hormone_R 490..767 CDD:320264 85/342 (25%)
TM helix 1 490..516 CDD:320264 8/25 (32%)
TM helix 2 524..549 CDD:320264 6/24 (25%)
TM helix 3 569..599 CDD:320264 9/29 (31%)
TM helix 4 611..633 CDD:320264 6/25 (24%)
TM helix 5 653..682 CDD:320264 12/29 (41%)
TM helix 6 692..725 CDD:320264 13/45 (29%)
TM helix 7 735..760 CDD:320264 8/24 (33%)
RXFP1NP_001240656.1 LDLa 27..62 CDD:238060
leucine-rich repeat 155..178 CDD:275380 2/22 (9%)
LRR <173..>387 CDD:443914 54/271 (20%)
leucine-rich repeat 179..202 CDD:275380 5/27 (19%)
leucine-rich repeat 203..226 CDD:275380 4/22 (18%)
leucine-rich repeat 227..250 CDD:275380 6/23 (26%)
leucine-rich repeat 251..275 CDD:275380 7/24 (29%)
leucine-rich repeat 276..299 CDD:275380 7/22 (32%)
leucine-rich repeat 300..323 CDD:275380 5/26 (19%)
leucine-rich repeat 324..347 CDD:275380 6/23 (26%)
leucine-rich repeat 348..371 CDD:275380 4/22 (18%)
leucine-rich repeat 372..393 CDD:275380 10/102 (10%)
7tmA_RXFP1_LGR7 433..719 CDD:320631 82/298 (28%)
TM helix 1 434..460 CDD:320631 8/25 (32%)
TM helix 2 467..492 CDD:320631 6/24 (25%)
TM helix 3 512..542 CDD:320631 9/29 (31%)
TM helix 4 553..575 CDD:320631 5/22 (23%)
TM helix 5 603..632 CDD:320631 12/28 (43%)
TM helix 6 648..678 CDD:320631 11/29 (38%)
TM helix 7 687..712 CDD:320631 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

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